[HTML][HTML] Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

[HTML][HTML] Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis

Y Chen, H Wang, Q Yang, W Zhao, Y Chen, Q Ni… - Theranostics, 2022 - ncbi.nlm.nih.gov
Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at
single-cell resolution. The osteoimmunology microenvironment in the occurrence and …

[HTML][HTML] Defining the skin cellular community using single-cell genomics to advance precision medicine

A Dubois, N Gopee, B Olabi, M Haniffa - Journal of Investigative …, 2021 - Elsevier
Single-cell genomics has revolutionized biological science, enabling high-resolution
analysis of human tissues. The ability to demonstrate the role and function of distinct cell …

[HTML][HTML] An elastic-net logistic regression approach to generate classifiers and gene signatures for types of immune cells and T helper cell subsets

A Torang, P Gupta, DJ Klinke - BMC bioinformatics, 2019 - Springer
Background Host immune response is coordinated by a variety of different specialized cell
types that vary in time and location. While host immune response can be studied using …

[HTML][HTML] Characterization of the bronchoalveolar lavage fluid by single cell gene expression analysis in healthy dogs: a promising technique

A Fastrès, D Pirottin, L Fievez, T Marichal… - Frontiers in …, 2020 - frontiersin.org
Single-cell mRNA-sequencing (scRNA-seq) is a technique which enables unbiased, high
throughput and high-resolution transcriptomic analysis of the heterogeneity of cells within a …

Arrestin beta‐2 deficiency exacerbates periodontal inflammation by mediating activating transcription factor 6 activation and abnormal remodelling of the extracellular …

M Feng, R Wang, L Deng, Y Yang, S Xia… - Journal of Clinical …, 2024 - Wiley Online Library
Aim To investigate the specific role of arrestin beta‐2 (ARRB2) in the progression of
periodontitis and the underlying mechanisms. Materials and Methods Single‐cell RNA …

[HTML][HTML] Single-cell RNA sequencing-based computational analysis to describe disease heterogeneity

T Zeng, H Dai - Frontiers in Genetics, 2019 - frontiersin.org
The trillions of cells in the human body can be viewed as elementary but essential biological
units that achieve different body states, but the low resolution of previous cell isolation and …

[HTML][HTML] Single-cell protein and RNA expression analysis of mononuclear phagocytes in intestinal mucosa and mesenteric lymph nodes of ulcerative colitis and …

L Chapuy, M Sarfati - Cells, 2020 - mdpi.com
Inflammatory bowel diseases (IBDs), which include Crohn's disease (CD) and ulcerative
colitis (UC), are driven by an abnormal immune response to commensal microbiota in …

[HTML][HTML] New insights into the interaction of the immune system with non-small cell lung carcinomas

P Hofman - Translational Lung Cancer Research, 2020 - ncbi.nlm.nih.gov
The basis of current and future lung cancer immunotherapy depends mainly on our
knowledge of the molecular mechanisms of interactions between cancer and immune cells …

Dissecting the human immune system with single cell RNA sequencing technology

G Xu, Y Liu, H Li, L Liu, S Zhang… - Journal of leukocyte …, 2020 - academic.oup.com
Single-cell RNA sequencing (scRNA-seq) is a powerful new technology allowing the
analysis of transcriptomes from individual cell and is ideally suited to dissect immune cell …