The Diversity of Escherichia coli Pathotypes and Vaccination Strategies against This Versatile Bacterial Pathogen

P Pokharel, S Dhakal, CM Dozois - Microorganisms, 2023 - mdpi.com
Escherichia coli (E. coli) is a gram-negative bacillus and resident of the normal intestinal
microbiota. However, some E. coli strains can cause diseases in humans, other mammals …

Recent advances in understanding enteric pathogenic Escherichia coli

MA Croxen, RJ Law, R Scholz… - Clinical microbiology …, 2013 - Am Soc Microbiol
Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also
has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases …

Intestinal Pathogenic Escherichia coli: Insights for Vaccine Development

M Rojas-Lopez, R Monterio, M Pizza… - Frontiers in …, 2018 - frontiersin.org
Diarrheal diseases are one of the major causes of mortality among children under five years
old and intestinal pathogenic Escherichia coli (InPEC) plays a role as one of the large …

Pre-existing immunity against vaccine vectors–friend or foe?

M Saxena, TTH Van, FJ Baird, PJ Coloe… - …, 2013 - microbiologyresearch.org
Over the last century, the successful attenuation of multiple bacterial and viral pathogens
has led to an effective, robust and safe form of vaccination. Recently, these vaccines have …

[HTML][HTML] Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing …

J Holmgren, L Bourgeois, N Carlin, J Clements… - Vaccine, 2013 - Elsevier
A first-generation oral inactivated whole-cell enterotoxigenic Escherichia coli (ETEC)
vaccine, comprising formalin-killed ETEC bacteria expressing different colonization factor …

Recent progress toward an enterotoxigenic Escherichia coli vaccine

AM Svennerholm, A Lundgren - Expert review of vaccines, 2012 - Taylor & Francis
Enterotoxigenic Escherichia coli (ETEC) is the most common cause of bacterial diarrhea in
children in Africa, Asia and Latin America and in travelers to these regions. Despite this, no …

From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development

AM Svennerholm - Indian Journal of Medical Research, 2011 - journals.lww.com
It was shown earlier that immune responses against cholera toxin (CT) as well as Vibrio
cholerae lipopolysaccharide (LPS) or whole bacterial cells (WC) were protective and that …

A combined vaccine approach against Vibrio cholerae and ETEC based on outer membrane vesicles

DR Leitner, S Lichtenegger, P Temel, FG Zingl… - Frontiers in …, 2015 - frontiersin.org
Enteric infections induced by pathogens like Vibrio cholerae and enterotoxigenic
Escherichia coli (ETEC) remain a massive burden in developing countries with increasing …

The Adjuvant Double Mutant Escherichia coli Heat Labile Toxin Enhances IL-17A Production in Human T Cells Specific for Bacterial Vaccine Antigens

S Leach, JD Clements, J Kaim, A Lundgren - PloS one, 2012 - journals.plos.org
The strong adjuvant activity and low enterotoxicity of the novel mucosal adjuvant double
mutant Escherichia coli heat labile toxin, LT (R192G/L211A) or dmLT, demonstrated in mice …

Development of Stable Vibrio cholerae O1 Hikojima Type Vaccine Strains Co–Expressing the Inaba and Ogawa Lipopolysaccharide Antigens

SL Karlsson, E Ax, E Nygren, S Källgård, M Blomquist… - PLoS one, 2014 - journals.plos.org
We describe here the development of stable classical and El Tor V. cholerae O1 strains of
the Hikojima serotype that co–express the Inaba and Ogawa antigens of O1 …