Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer
Chemotherapy resistance is a critical contributor to cancer mortality and thus an urgent
unmet challenge in oncology. To characterize chemotherapy resistance processes in high …
unmet challenge in oncology. To characterize chemotherapy resistance processes in high …
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …
SCENIC: single-cell regulatory network inference and clustering
S Aibar, CB González-Blas, T Moerman… - Nature …, 2017 - nature.com
We present SCENIC, a computational method for simultaneous gene regulatory network
reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic …
reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic …
Anaplastic transformation in thyroid cancer revealed by single-cell transcriptomics
The deadliest anaplastic thyroid cancer (ATC) often transforms from indolent differentiated
thyroid cancer (DTC); however, the complex intratumor transformation process is poorly …
thyroid cancer (DTC); however, the complex intratumor transformation process is poorly …
Integrated cross-study datasets of genetic dependencies in cancer
C Pacini, JM Dempster, I Boyle, E Gonçalves… - Nature …, 2021 - nature.com
CRISPR-Cas9 viability screens are increasingly performed at a genome-wide scale across
large panels of cell lines to identify new therapeutic targets for precision cancer therapy …
large panels of cell lines to identify new therapeutic targets for precision cancer therapy …
A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome
P Soret, C Le Dantec, E Desvaux, N Foulquier… - Nature …, 2021 - nature.com
There is currently no approved treatment for primary Sjögren's syndrome, a disease that
primarily affects adult women. The difficulty in developing effective therapies is-in part …
primarily affects adult women. The difficulty in developing effective therapies is-in part …
Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts
It is estimated that 350 million individuals worldwide suffer from rare diseases, which are
predominantly caused by mutation in a single gene. The current molecular diagnostic rate is …
predominantly caused by mutation in a single gene. The current molecular diagnostic rate is …
Analysis of wild tomato introgression lines elucidates the genetic basis of transcriptome and metabolome variation underlying fruit traits and pathogen response
Wild tomato species represent a rich gene pool for numerous desirable traits lost during
domestication. Here, we exploited an introgression population representing wild desert …
domestication. Here, we exploited an introgression population representing wild desert …
[HTML][HTML] Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA
A common limitation of neuroimaging studies is their small sample sizes. To overcome this
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) …
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) …
The protective effects of live and pasteurized Akkermansia muciniphila and its extracellular vesicles against HFD/CCl4-induced liver injury
S Keshavarz Azizi Raftar, F Ashrafian… - Microbiology …, 2021 - Am Soc Microbiol
Akkermansia muciniphila, as a member of the gut microbiota, has been proposed as a next-
generation probiotic. Liver fibrosis is the main determinant of liver dysfunction and mortality …
generation probiotic. Liver fibrosis is the main determinant of liver dysfunction and mortality …