Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

The fragments that derive from transfer RNAs (tRNAs) are an emerging category of
regulatory RNAs. Known as tRFs, these fragments were reported for the first time only a …

tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …

Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …

The participation of tRNAs in fundamental aspects of biology and disease necessitates an
accurate, experimentally confirmed annotation of tRNA genes and curation of tRNA …

Functional analysis of the proteome is an essential part of genomic research. To facilitate
different proteomic approaches, a MORF (moveable ORF) library of 5854 yeast expression …

As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …

Transfer RNAs (tRNAs) are essential for protein synthesis. In eukaryotes, tRNA biosynthesis
employs a specialized RNA polymerase that generates initial transcripts that must be …

Mature tRNA is normally extensively modified and extremely stable. Recent evidence
suggests that hypomodified mature tRNA in yeast can undergo a quality control check by a …