Telomerase and the control of telomere length are intimately linked to the process of
tumourigenesis in humans. Here I review the evidence that variation at the 5p15. 33 locus …

Proteomics is increasingly employed in both neurological and oncological research to
provide insight into the molecular basis of disease but rarely has a coherent, novel …

To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide
association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 …

Background There are controversial results concerning the prognostic implication of TERT
promoter mutation in glioma patients concerning MGMT status. In this meta-analysis, we …

Two genome-wide association studies of glioma in European populations identified 14
genetic variants strongly associated with risk of glioma, but it is unknown whether these …

Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have
been associated with good prognosis for patients with brain neoplasias and have been …

Recent advances in human genome studies have opened new avenues for the identification
of susceptibility genes for many complex genetic disorders, especially in the field of rare …

Aim: To review the impact of molecular biomarkers on response to therapy and survival in
patients with primary glioblastoma (GBM). Materials & Methods: Tissue specimens were …

Despite the increasing knowledge about the genetic alterations and molecular pathways
involved in gliomas, few studies have investigated the association between the gene …

Glioblastoma multiforme (GBM) has a poor prognosis despite maximal multimodal therapy.
Biomarkers of relevance to prognosis which may also identify treatment targets are needed …