The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Scavenger receptors were originally identified by their ability to recognize and to remove
modified lipoproteins; however, it is now appreciated that they carry out a striking range of …

Adipose tissues dynamically remodel their cellular composition in response to external cues
by stimulating beige adipocyte biogenesis; however, the developmental origin and …

Retinal pigment epithelial cells (RPE) constitute a simple layer of cuboidal cells that are
strategically situated behind the photoreceptor (PR) cells. The inconspicuousness of this …

Membrane lipids and proteins are non-randomly distributed and are unable to diffuse freely
in the plane of the membrane. This is because of multiple constraints imposed both by the …

Photoreceptor cells maintain a roughly constant length by continuously generating new
outer segments from their base while simultaneously releasing mature outer segments …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide.
Drusen are key contributors to the etiology of AMD and the ability to modulate drusen …

RPE cells are the most actively phagocytic cells in the human body. In the eye, RPE cells
face rod and cone photoreceptor outer segments at all times but contribute to shedding and …

Age-related macular degeneration (AMD) is a major cause of loss of central vision in the
elderly. The formation of drusen, an extracellular, amorphous deposit of material on Bruch's …