Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

Depression is common, costly, debilitating, and associated with increased risk of suicide. It is
one of the leading global public health problems. Although existing available …

Background Psilocybin is being studied for use in treatment-resistant depression. Methods
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant …

Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …

Psilocybin therapy shows antidepressant potential, but its therapeutic actions are not well
understood. We assessed the subacute impact of psilocybin on brain function in two clinical …

Importance Although classic psychedelic medications have shown promise in the treatment
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …

Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …

There is considerable interest in screening ultralarge chemical libraries for ligand discovery,
both empirically and computationally,,–. Efforts have focused on readily synthesizable …

Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …

Background Psilocybin has been suggested as a novel, rapid-acting treatment for
depression. Two consecutive doses have been shown to markedly decrease symptom …