Microplastic pollution is a major threat to the marine environment attracting attention from
scientific and public communities. Although we have sufficient evidence that microplastic is …

Membrane transporters can be major determinants of the pharmacokinetic, safety and
efficacy profiles of drugs. This presents several key questions for drug development …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Microcystins (MC) are potent hepatotoxins produced by the cyanobacteria of the genera
Planktothrix, Microcystis, Aphanizomenon, Nostoc and Anabaena. These cyclic …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that positively
regulates the basal and inducible expression of a large battery of cytoprotective genes …

Introduction: Drug transporters play an important role in the absorption, distribution, and
excretion (ADE) of many drugs. In the last several years it has become increasingly clear …

The impact of a microplastic (MP) mixture composed of polyethylene (PE) and
polypropylene (PP) plastic particles, prepared from commercially available products, was …

Studies on the increasing number of transporters found in the placental barrier are gaining
momentum, because of their tissue‐specific expression, significance in physiology and …

Currently, information regarding concentrations of chlorinated polyfluoroalkyl ether sulfonic
acids (Cl-PFESAs) in human placenta does not exist. The main objective of this study was to …

This white paper provides a critical analysis of methods for estimating transporter kinetics
and recommendations on proper parameter calculation in various experimental systems …