The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

The bone marrow constitutes the primary site for life-long blood production and skeletal
regeneration. However, its cellular and spatial organization remains controversial. Here, we …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has
prevailed throughout the past decade. However, recent high-throughput, high-resolution …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament
initially characterized in neural stem cells. However, current extensive evidence obtained in …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …