Identification and confirmation of bioactive small‐molecule targets is a crucial, often decisive
step both in academic and pharmaceutical research. Through the development and …

Target identification is an essential part of the drug discovery and development process, and
its efficacy plays a crucial role in the success of any given therapy. Although protein target …

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Background To efficiently supply ATP to sites of high-energy demand and finely regulate
calcium signaling, mitochondria adapt their metabolism, shape, and distribution within the …

Melanosomes are specialized membrane-bound organelles that synthesize and organize
melanin, ultimately providing color to the skin, hair, and eyes. Disorders in melanogenesis …

There is an urgent need to discover new compounds that effectively treat diabetes by
mimicking the action of insulin (insulin mimetics). Traditional approaches to studying anti …

Bioactive compounds can be used to selectively modulate gene function. We utilized a
chemical genetic approach to dissect the mammalian pigmentation pathway and identify …

Melanin, a ubiquitous dark pigment, plays important roles in the immune system, including
scavenging reactive oxygen species formed in response to ultraviolet radiation absorption …

A new strategy for constructing large Stokes shift dyes by coupling a low quantum yield (less
than 1%) BODIPY donor (BDN) with tunable high quantum yield BODIPY acceptors (BDM) …

Insulin and insulin-like growth factor have an essential role in growth, development and the
maintenance of metabolic homeostasis, including glucose uptake from the bloodstream …