Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various
mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, the reduced …

Abstract The Cancer Programme of the 100,000 Genomes Project was an initiative to
provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities …

Historically, the primary focus of cancer research has been molecular and clinical studies of
a few essential pathways and genes. Recent years have seen the rapid accumulation of …

Background Predictive biomarkers are essential for selecting the best therapeutic strategy in
patients with cancer. The International Quality Network for Pathology, the European Cancer …

Metastatic relapse after treatment is the leading cause of cancer mortality, and known
resistance mechanisms are missing for most treatments administered to patients. To bridge …

Plasma circulating tumor DNA (ctDNA) represents short fragments of tumor-derived DNA
released into the bloodstream primarily from cancer cells undergoing apoptosis. In …

Ferroptosis is a programmed, iron-dependent, oxidative cell death that was discovered
recently. It is usually accompanied by iron accumulation and lipid peroxidation during the …

In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

There is emerging evidence about the predictive role of homologous recombination
deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies …