The enigmatic X gene of hepatitis B virus
MJ Bouchard, RJ Schneider - Journal of virology, 2004 - Am Soc Microbiol
With an estimate of 350 million people chronically infected with the hepatitis B virus (HBV)
worldwide, it is critically important to understand how persistent HBV infection is maintained …
worldwide, it is critically important to understand how persistent HBV infection is maintained …
DNA viruses and the cellular DNA-damage response
AS Turnell, RJ Grand - Journal of General Virology, 2012 - microbiologyresearch.org
It is clear that a number of host-cell factors facilitate virus replication and, conversely, a
number of other factors possess inherent antiviral activity. Research, particularly over the …
number of other factors possess inherent antiviral activity. Research, particularly over the …
The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells
The damaged-DNA binding protein DDB consists of two subunits, DDB1 (127 kDa) and
DDB2 (48 kDa). Mutations in the DDB2 subunit have been detected in patients suffering …
DDB2 (48 kDa). Mutations in the DDB2 subunit have been detected in patients suffering …
Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions
B Iovine, ML Iannella, MA Bevilacqua - The international journal of …, 2011 - Elsevier
Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first
isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA …
isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA …
True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product
V Rapić-Otrin, V Navazza, T Nardo… - Human molecular …, 2003 - academic.oup.com
Xeroderma pigmentosum (XP) is a skin cancer-prone autosomal recessive disease
characterized by inability to repair UV-induced DNA damage. The major form of XP is …
characterized by inability to repair UV-induced DNA damage. The major form of XP is …
Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome
T Bondar, A Kalinina, L Khair, D Kopanja… - … and cellular biology, 2006 - Am Soc Microbiol
DDB1, a subunit of the damaged-DNA binding protein DDB, has been shown to function
also as an adaptor for Cul4A, a member of the cullin family of E3 ubiquitin ligase. The Cul4A …
also as an adaptor for Cul4A, a member of the cullin family of E3 ubiquitin ligase. The Cul4A …
Tumor-prone phenotype of the DDB2-deficient mice
T Yoon, A Chakrabortty, R Franks, T Valli, H Kiyokawa… - Oncogene, 2005 - nature.com
DDB2 is an essential subunit of the damaged-DNA recognition factor DDB, which is involved
in global genomic repair in human cells. Moreover, DDB2 is mutated in the repair-deficiency …
in global genomic repair in human cells. Moreover, DDB2 is mutated in the repair-deficiency …
Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis
Y Matsuda, T Ichida - Medical molecular morphology, 2009 - Springer
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide.
The main HCC-associated diseases are chronic infections with hepatitis B virus (HBV) and …
The main HCC-associated diseases are chronic infections with hepatitis B virus (HBV) and …
[HTML][HTML] Rapid hepatocyte nuclear translocation of the Forkhead Box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic …
X Wang, D Bhattacharyya, MB Dennewitz… - Gene …, 2003 - ncbi.nlm.nih.gov
Abstract The Forkhead Box (Fox) proteins are an extensive family of transcription factors that
shares homology in the winged helix DNA binding domain. Liver regeneration studies with …
shares homology in the winged helix DNA binding domain. Liver regeneration studies with …
Proteomic analysis of nuclear hepatitis B virus relaxed circular DNA-associated proteins identifies UV-damaged DNA binding protein as a host factor involved in …
Hepatitis B virus (HBV) utilizes host DNA repair mechanisms to convert viral relaxed circular
DNA (rcDNA) into a persistent viral genome, the covalently closed circular DNA (cccDNA) …
DNA (rcDNA) into a persistent viral genome, the covalently closed circular DNA (cccDNA) …