Background As in other fields of medicine, development of new medications for
management of neuropathic pain has been difficult since preclinical rodent models do not …

C-tactile (CT) afferents were long-believed to be lacking in humans, but these were
subsequently shown to densely innervate the face and arm skin, and to a lesser extent the …

Highlights•Human and animal studies suggest a possible role for C-LTMRs in
allodynia.•Activation of C-LTMRs may also alleviate pain in some contexts.•Diverse synaptic …

Sensory processing sensitivity is described as a personality trait associated with a high
sensitivity to environmental and social stimuli. It has been assumed that about 15–20% of …

Abstract C-tactile (CT) fibers, responsible for the so-called “affective” touch (AT), have drawn
a fair amount of attention within the scientific community for their marked social dimension …

Cutaneous vibration is able to reduce both clinical and experimental pain, an effect called
vibratory analgesia. The traditional explanation for this phenomenon is that it is mediated by …

The emotion generated by the touch of materials is studied via a protocol based on blind
assessment of various stimuli. The human emotional reaction felt toward a material is …

Therapeutic affective touch has been recognized as essential for survival, nurturing
supportive interpersonal interactions, accelerating recovery—including reducing …

It is generally agreed that cold allodynia is a consequence of impaired (Ad-fibre-mediated)
central inhibition of C-nociceptive inputs. However, it is also known that C polymodal …

The mammalian skin in innervated by distinct classes of low-threshold mechanoreceptive
(LTM) primary afferent neurons that are classified as Aβ-, Aδ-or C-LTMs according to their …