Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

Parkinson's disease (PD) is characterized by an abnormal post-translational modifications
(PTM) in amino acid sequence and aggregation of alpha-synuclein (α-Syn) protein. It is …

Manganese (Mn) is one of the most abundant metals on the earth. It is required for normal
cellular activities, but overexposure leads to toxicity. Neurons are more susceptible to Mn …

The deposition of fibrillar alpha-synuclein (α-syn) within inclusions (Lewy bodies and Lewy
neurites) in neurons and glial cells is a hallmark of synucleinopathies. α-syn populates a …

Several studies have proposed that fibrillary aggregates of tau and other amyloidogenic
proteins are neurotoxic and result in numerous neurodegenerative diseases. However …

Aberrant aggregation and amyloid formation of tar DNA binding protein (TDP-43) and α-
synuclein (αS) underlie frontotemporal dementia (FTD) and Parkinson's disease (PD) …

Protein fibrils drive the onset and progression of many diseases in a prion-like manner, ie
they transcellular propagate through the extracellular space to health cells to initiate toxic …

An increasing number of neurodegenerative diseases are being found to be associated with
the abnormal accumulation of aggregated proteins in the brain. In Parkinson's disease, this …

A host of human diseases, including Parkinson's disease and Dementia with Lewy bodies,
are suspected to be directly linked to protein aggregation. Amyloid protein aggregates and …

A contribution of α‐Synuclein (α‐Syn) to etiology of Parkinson´ s disease (PD) and Dementia
with Lewy bodies (DLB) is currently undisputed, while the impact of the closely related β …