Embryonic development hinges on effective coordination of molecular events across space
and time. Waves have recently emerged as constituting an ubiquitous mechanism that …

The mechanisms underpinning the formation of patterned cellular landscapes has been the
subject of extensive study as a fundamental problem of developmental biology. In most …

The metameric pattern of somites is created based on oscillatory expression of clock genes
in presomitic mesoderm. However, the mechanism for converting the dynamic oscillation to …

The intricate dynamics of Hes expression across diverse cell types in the developing
vertebrate embryonic tail have remained elusive. To address this, we have developed an …

Visualizing, tracking and reconstructing cell lineages in developing embryos has been an
ongoing effort for well over a century. Recent advances in light microscopy, labelling …

Proper vertebrae formation relies on a tissue-wide oscillator called the segmentation clock.
Individual cellular oscillators in the presomitic mesoderm are modulated by intercellular …

The ability to quantify transcriptional dynamics in individual cells via live imaging has
revolutionized our understanding of gene regulation. However, such measurements are …

Abstract The Segmentation Clock is a tissue-level patterning system that enables the
segmentation of the vertebral column precursors into transient multicellular blocks called …

Tight spatiotemporal control of cellular behavior and cell fate decisions is paramount to the
formation of multicellular organisms during embryonic development. Intercellular …

Classic microsurgical techniques, such as those used in the early 1900s by Mangold and
Spemann, have been instrumental in advancing our understanding of embryonic …