Metal compounds against neglected tropical diseases

YC Ong, S Roy, PC Andrews, G Gasser - Chemical reviews, 2018 - ACS Publications
Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

CB Scarim, RL de Farias, AV de Godoy Netto… - European Journal of …, 2021 - Elsevier
Metal-based drugs are privileged motifs that act as primary pharmacophores in bioactive
compounds for various diseases, including tuberculosis (TB). This potentially life-threatening …

Construction of charge-switchable and pH-sensitive carboxymethyl chitosan/Zn2+/heterocycle nanocomposite for the treatment of phytopathogens in agriculture

X Liang, G Bai, C Niu, Y Feng, Z Wei, Z Lei… - Chemical Engineering …, 2023 - Elsevier
Bacterial and fungal infections have resulted in serious crop diseases, posing severe threats
to food security. There is an urgent need to develop innovative antibacterial strategies to …

Recent advances in 1, 2, 4-triazolo [1, 5-a] pyrimidine chemistry

G Fischer - Advances in Heterocyclic Chemistry, 2019 - Elsevier
The review deals with the pharmaceutically and agrochemically important group of 1, 2, 4-
triazolo [1, 5-a] pyrimidines (TPs) and covers relevant literature published from about 2006 …

Metallodrugs for the treatment of trypanosomatid diseases: Recent advances and new insights

M Navarro, RMS Justo, GYS Delgado… - Current …, 2021 - benthamdirect.com
Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs).
NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and …

[HTML][HTML] First-Row Transition 7-Oxo-5-phenyl-1, 2, 4-triazolo [1, 5-a] pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies

Á Martín-Montes, S Jimenez-Falcao, S Gómez-Ruiz… - Pharmaceuticals, 2023 - mdpi.com
Leishmaniasis and Chagas disease are still considered neglected illnesses due to the lack
of investment in research, despite the fact that almost one million new cases are reported …

[HTML][HTML] Biological activity of triazolopyrimidine copper (II) complexes modulated by an auxiliary NN-chelating heterocycle ligands

LL Ruta, IC Farcasanu, M Bacalum, M Răileanu… - Molecules, 2021 - mdpi.com
Novel complexes of type [Cu (NN)(dmtp) 2 (OH2)](ClO4) 2· dmtp ((1) NN: 2, 2′-
bipyridine;(2) L: 1, 10-phenantroline and dmtp: 5, 7-dimethyl-1, 2, 4-triazolo [1, 5-a] …

In vitro leishmanicidal and trypanocidal evaluation and magnetic properties of 7-amino-1, 2, 4-triazolo [1, 5-a] pyrimidine Cu (II) complexes

JM Méndez-Arriaga, I Oyarzabal, G Escolano… - Journal of inorganic …, 2018 - Elsevier
Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1, 2,
4-triazolo [1, 5-a] pyrimidine (7atp) and Cu (II) salts. Crystal structures of [Cu 2 (μ-7atp) 4 Cl …

[HTML][HTML] Recent Advances in Metal Complexes Based on Biomimetic and Biocompatible Organic Ligands against Leishmaniasis Infections: State of the Art and …

S Jimenez-Falcao, JM Mendez-Arriaga - Inorganics, 2024 - mdpi.com
Leishmaniasis is a complex disease present in a variety of manifestations listed by the World
Health Organization (WHO) as one of the neglected diseases with a worse prognosis if not …

[HTML][HTML] Antiparasitic Activity of Oxindolimine–Metal Complexes against Chagas Disease

MC Portes, GA Ribeiro, GL Sabino, RAA De Couto… - Inorganics, 2023 - mdpi.com
Some copper (II) and zinc (II) complexes with oxindolimine ligands were tested regarding
their trypanocidal properties. These complexes have already shown good biological activity …