The impact of hypoxia in early pregnancy on placental cells
H Zhao, RJ Wong, DK Stevenson - International journal of molecular …, 2021 - mdpi.com
Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …
Human chorionic villous differentiation and placental development
J Kojima, M Ono, N Kuji, H Nishi - International Journal of Molecular …, 2022 - mdpi.com
In humans, the placenta provides the only fetomaternal connection and is essential for
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …
[HTML][HTML] Clinical and in vitro evidence against placenta infection at term by severe acute respiratory syndrome coronavirus 2
Despite occasional reports of vertical transmission of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) during pregnancy, the question of placental infection and its …
coronavirus 2 (SARS-CoV-2) during pregnancy, the question of placental infection and its …
[HTML][HTML] Iron metabolism and ferroptosis: A pathway for understanding preeclampsia
KE Gumilar, B Priangga, CH Lu, EG Dachlan… - Biomedicine & …, 2023 - Elsevier
Preeclampsia (PE) is a serious medical condition that poses a significant health risk to
women and children worldwide, particularly in the middle-and low-income countries. It is a …
women and children worldwide, particularly in the middle-and low-income countries. It is a …
Mechanistic insights into the development of severe fetal growth restriction
DL Gumina, EJ Su - Clinical Science, 2023 - portlandpress.com
Fetal growth restriction (FGR), which most commonly results from suboptimal placental
function, substantially increases risks for adverse perinatal and long-term outcomes. The …
function, substantially increases risks for adverse perinatal and long-term outcomes. The …
From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes
Placental hypoxia poses significant risks to both the developing fetus and the mother during
pregnancy, underscoring the importance of early detection and monitoring. Effectively …
pregnancy, underscoring the importance of early detection and monitoring. Effectively …
miR-181d-5p, which is upregulated in fetal growth restriction placentas, inhibits trophoblast fusion via CREBRF
ZH Wu, FF Li, LL Ruan, Q Feng, S Zhang, ZH Li… - Journal of assisted …, 2023 - Springer
Purpose Fetal growth restriction (FGR) is a common complication characterized by impaired
placental function and unfavorable pregnancy outcomes. This study aims to elucidate the …
placental function and unfavorable pregnancy outcomes. This study aims to elucidate the …
[HTML][HTML] Evidence for hypoxia‐induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues
Preeclampsia (PE) poses a considerable risk to the long‐term cardiovascular health of both
mothers and their offspring due to a hypoxic environment in the placenta leading to reduced …
mothers and their offspring due to a hypoxic environment in the placenta leading to reduced …
Controlling Trophoblast Cell Fusion in the Human Placenta—Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1
J Sugimoto, DJ Schust, M Sugimoto, Y Jinno, Y Kudo - Biomolecules, 2023 - mdpi.com
Cell fusion in the placenta is tightly regulated. Suppressyn is a human placental
endogenous retroviral protein that inhibits the profusogenic activities of another well …
endogenous retroviral protein that inhibits the profusogenic activities of another well …