The impact of hypoxia in early pregnancy on placental cells

H Zhao, RJ Wong, DK Stevenson - International journal of molecular …, 2021 - mdpi.com
Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Human chorionic villous differentiation and placental development

J Kojima, M Ono, N Kuji, H Nishi - International Journal of Molecular …, 2022 - mdpi.com
In humans, the placenta provides the only fetomaternal connection and is essential for
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …

[HTML][HTML] Clinical and in vitro evidence against placenta infection at term by severe acute respiratory syndrome coronavirus 2

A Colson, CL Depoix, G Dessilly, P Baldin… - The American journal of …, 2021 - Elsevier
Despite occasional reports of vertical transmission of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) during pregnancy, the question of placental infection and its …

[HTML][HTML] Iron metabolism and ferroptosis: A pathway for understanding preeclampsia

KE Gumilar, B Priangga, CH Lu, EG Dachlan… - Biomedicine & …, 2023 - Elsevier
Preeclampsia (PE) is a serious medical condition that poses a significant health risk to
women and children worldwide, particularly in the middle-and low-income countries. It is a …

Mechanistic insights into the development of severe fetal growth restriction

DL Gumina, EJ Su - Clinical Science, 2023 - portlandpress.com
Fetal growth restriction (FGR), which most commonly results from suboptimal placental
function, substantially increases risks for adverse perinatal and long-term outcomes. The …

From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes

FM Al Darwish, L Meijerink, BF Coolen, GJ Strijkers… - Cells, 2023 - mdpi.com
Placental hypoxia poses significant risks to both the developing fetus and the mother during
pregnancy, underscoring the importance of early detection and monitoring. Effectively …

miR-181d-5p, which is upregulated in fetal growth restriction placentas, inhibits trophoblast fusion via CREBRF

ZH Wu, FF Li, LL Ruan, Q Feng, S Zhang, ZH Li… - Journal of assisted …, 2023 - Springer
Purpose Fetal growth restriction (FGR) is a common complication characterized by impaired
placental function and unfavorable pregnancy outcomes. This study aims to elucidate the …

[HTML][HTML] Evidence for hypoxia‐induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues

B Fuenzalida, MJ Yañez, M Mueller, HD Mistry… - The FASEB …, 2024 - ncbi.nlm.nih.gov
Preeclampsia (PE) poses a considerable risk to the long‐term cardiovascular health of both
mothers and their offspring due to a hypoxic environment in the placenta leading to reduced …

Controlling Trophoblast Cell Fusion in the Human Placenta—Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1

J Sugimoto, DJ Schust, M Sugimoto, Y Jinno, Y Kudo - Biomolecules, 2023 - mdpi.com
Cell fusion in the placenta is tightly regulated. Suppressyn is a human placental
endogenous retroviral protein that inhibits the profusogenic activities of another well …