Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of
extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair …

Bone morphogenetic proteins (BMPs) are secreted cytokines that were initially discovered
on the basis of their ability to induce bone. Several decades of research have now …

Heterotopic ossification (HO) is the formation of extraskeletal bone in non-osseous tissues. It
is caused by an injury that stimulates abnormal tissue healing and regeneration, and …

Tendon injuries disrupt the balance between stability and mobility, causing compromised
functions and disabilities. The regeneration of mature, functional tendons remains a clinical …

To date, the cell and molecular mechanisms regulating tendon healing are poorly
understood. Here, we establish a novel model of tendon regeneration using neonatal mice …

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder
characterized by progressive and profoundly disabling heterotopic ossification (HO). Here …

Acquired heterotopic ossification (HO) is a painful and debilitating disease characterized by
extraskeletal bone formation after injury. The exact pathogenesis of HO remains unknown …

Normal skeletal muscle functions are affected following trauma, chronic diseases, inherited
neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of …

Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the
most important functions of these metabolically active cells is mineralized matrix production …