Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

Transforming growth factor β (TGF-β) signaling pathway plays important roles in many
biological processes, including cell growth, differentiation, apoptosis, migration, as well as …

Colorectal cancer (CRC) accounts for over 8% of all deaths annually worldwide. Between 2
and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial …

Context.—Familial adenomatous polyposis (FAP) is a rare genetic disorder with autosomal
dominant inheritance, defined by numerous adenomatous polyps, which inevitably progress …

Signaling initiated by secreted glycoproteins of the Wnt family regulates many aspects of
embryonic development and it is involved in homeostasis of adult tissues. In the …

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

Purpose Desmoid tumors (aggressive fibromatosis) arise from connective tissue cells or
fibroblasts. In general, they are slow growing and do not metastasize; however, locally …

Notch signaling is a highly conserved signal transduction pathway that regulates stem cell
maintenance and differentiation in several organ systems. Upon activation, the Notch …

2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …