[HTML][HTML] PGC-1α protects RPE cells of the aging retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality …
K Kaarniranta, J Kajdanek, J Morawiec… - International journal of …, 2018 - mdpi.com
PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is a
transcriptional coactivator of many genes involved in energy management and …
transcriptional coactivator of many genes involved in energy management and …
The endoplasmic reticulum: homeostasis and crosstalk in retinal health and disease
The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …
range of important cellular functions including protein biosynthesis, folding, and trafficking …
[HTML][HTML] Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation
A virus that reproduces in a host without killing cells can easily establish a successful
infection. Previously, we showed that dengue-2, a virus that threatens 40% of the world …
infection. Previously, we showed that dengue-2, a virus that threatens 40% of the world …
[HTML][HTML] SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING …
X Zhuang, J Ma, G Xu, Z Sun - Molecular Medicine, 2022 - Springer
Background Oxidative stress-caused damage to the retinal pigment epithelium (RPE)
underlies the onset and progression of age-related macular degeneration (AMD). Impaired …
underlies the onset and progression of age-related macular degeneration (AMD). Impaired …
Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal
C Chen, K Yang, D He, B Yang, L Tao, J Chen… - Free Radical Biology and …, 2023 - Elsevier
The accumulation of all-trans-retinal (atRAL) in photoreceptors and the retinal pigment
epithelium (RPE), which is induced by chaos in visual (retinoid) cycle, is closely associated …
epithelium (RPE), which is induced by chaos in visual (retinoid) cycle, is closely associated …
Photo-oxidative blue-light stimulation in retinal pigment epithelium cells promotes exosome secretion and increases the activity of the NLRP3 inflammasome
W Zhang, Y Ma, Y Zhang, J Yang, G He… - Current eye …, 2019 - Taylor & Francis
Purpose: Age-related macular degeneration (AMD) is a major cause of blindness in the
elderly, and the activation of the NACHT, LRR, and PYD domain-containing protein 3 …
elderly, and the activation of the NACHT, LRR, and PYD domain-containing protein 3 …
[HTML][HTML] Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal
Y Liao, H Zhang, D He, Y Wang, B Cai… - … & visual science, 2019 - iovs.arvojournals.org
Purpose: Visual (retinoid) cycle anomalies induce aberrant build-up of all-trans retinal
(atRAL) in the retinal pigment epithelium (RPE), which is a cause of RPE atrophy in …
(atRAL) in the retinal pigment epithelium (RPE), which is a cause of RPE atrophy in …
Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells
L Zhang, Q Xia, Y Zhou, J Li - Toxicology Letters, 2019 - Elsevier
Excessive accumulation of cadmium (Cd) in retina plays an important role in tobacco
smoking-associated age-related macular degeneration (AMD). Plenty of evidence has …
smoking-associated age-related macular degeneration (AMD). Plenty of evidence has …
[HTML][HTML] Chrysin ameliorates malfunction of retinoid visual cycle through blocking activation of AGE-RAGE-ER stress in glucose-stimulated retinal pigment epithelial …
MK Kang, EJ Lee, YH Kim, DY Kim, H Oh, SI Kim… - Nutrients, 2018 - mdpi.com
Diabetes-associated visual cycle impairment has been implicated in diabetic retinopathy,
and chronic hyperglycemia causes detrimental effects on visual function. Chrysin, a naturally …
and chronic hyperglycemia causes detrimental effects on visual function. Chrysin, a naturally …
[HTML][HTML] eIF2α incites photoreceptor cell and retina damage by all-trans-retinal
D He, L Tao, B Cai, X Chen, Y Wang, S Li… - Journal of Biological …, 2023 - ASBMB
Dry age-related macular degeneration (AMD) and recessive Stargardt's disease (STGD1)
lead to irreversible blindness in humans. The accumulation of all-trans-retinal (atRAL) …
lead to irreversible blindness in humans. The accumulation of all-trans-retinal (atRAL) …