Molecular pathogenesis and systemic therapies for hepatocellular carcinoma
JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …
The poor outcome associated with HCC is dramatically changing due to the advent of …
[HTML][HTML] Impact of aging on primary liver cancer: epidemiology, pathogenesis and therapeutics
Aging involves progressive physiological and metabolic reprogramming to adapt to gradual
deterioration of organs and functions. This includes mechanisms of defense against pre …
deterioration of organs and functions. This includes mechanisms of defense against pre …
Integrated genomic analysis identifies driver genes and cisplatin-resistant progenitor phenotype in pediatric liver cancer
TZ Hirsch, J Pilet, G Morcrette, A Roehrig, BJE Monteiro… - Cancer discovery, 2021 - AACR
Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and
adolescents. Despite overall good prognosis, PLCs display heterogeneous response to …
adolescents. Despite overall good prognosis, PLCs display heterogeneous response to …
Bi-allelic hydroxymethylbilane synthase inactivation defines a homogenous clinico-molecular subtype of hepatocellular carcinoma
Background & Aims Acute intermittent porphyria (AIP), caused by heterozygous germline
mutations of the heme synthesis pathway enzyme HMBS (hydroxymethylbilane synthase) …
mutations of the heme synthesis pathway enzyme HMBS (hydroxymethylbilane synthase) …
[HTML][HTML] Conserved methylation signatures associate with the tumor immune microenvironment and immunotherapy response
Q Qin, Y Zhou, J Guo, Q Chen, W Tang, Y Li, J You… - Genome Medicine, 2024 - Springer
Background Aberrant DNA methylation is a major characteristic of cancer genomes. It
remains unclear which biological processes determine epigenetic reprogramming and how …
remains unclear which biological processes determine epigenetic reprogramming and how …
N6-Methyladenosine-Modified LEAWBIH Drives Hepatocellular Carcinoma Progression through Epigenetically Activating Wnt/β-Catenin Signaling
H Wei, L Huang, Q Lu, Z Huang, Y Huang… - Journal of …, 2023 - Taylor & Francis
Purpose N6-methyladenosine (m6A) modification plays an important role in regulating RNA
maturation, stability, and translation. Thus, m6A modification is involved in various …
maturation, stability, and translation. Thus, m6A modification is involved in various …
Epigenetic remodelling in human hepatocellular carcinoma
MR Braghini, O Lo Re, I Romito… - Journal of Experimental …, 2022 - Springer
Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer, being the sixth
most commonly diagnosed cancer and the fourth leading cause of cancer-related death. As …
most commonly diagnosed cancer and the fourth leading cause of cancer-related death. As …
DNA methylation regulates a set of long non-coding RNAs compromising hepatic identity during hepatocarcinogenesis
M Recalde, M Gárate-Rascón, JM Herranz, M Elizalde… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocarcinogenesis is a long process which implies the loss of hepatic
functions. Our effort is to understand the mechanisms implicated in this pathological process …
functions. Our effort is to understand the mechanisms implicated in this pathological process …
The roles of lncRNA functions and regulatory mechanisms in the diagnosis and treatment of hepatocellular carcinoma
Y Hong, Y Zhang, H Zhao, H Chen, QQ Yu… - Frontiers in Cell and …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most frequent and deadly type of liver cancer. While
the underlying molecular mechanisms are poorly understood, it is documented that lncRNAs …
the underlying molecular mechanisms are poorly understood, it is documented that lncRNAs …
Methylated circulating tumor DNA in hepatocellular carcinoma: A comprehensive analysis of biomarker potential and clinical implications
Q Zhu, J Xie, W Mei, C Zeng - Cancer Treatment Reviews, 2024 - Elsevier
The intricate epigenetic landscape of hepatocellular carcinoma (HCC) is profoundly
influenced by alterations in DNA methylation patterns. Understanding these alterations is …
influenced by alterations in DNA methylation patterns. Understanding these alterations is …