Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Aging involves progressive physiological and metabolic reprogramming to adapt to gradual
deterioration of organs and functions. This includes mechanisms of defense against pre …

Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and
adolescents. Despite overall good prognosis, PLCs display heterogeneous response to …

Background & Aims Acute intermittent porphyria (AIP), caused by heterozygous germline
mutations of the heme synthesis pathway enzyme HMBS (hydroxymethylbilane synthase) …

Background Aberrant DNA methylation is a major characteristic of cancer genomes. It
remains unclear which biological processes determine epigenetic reprogramming and how …

Purpose N6-methyladenosine (m6A) modification plays an important role in regulating RNA
maturation, stability, and translation. Thus, m6A modification is involved in various …

Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer, being the sixth
most commonly diagnosed cancer and the fourth leading cause of cancer-related death. As …

Simple Summary Hepatocarcinogenesis is a long process which implies the loss of hepatic
functions. Our effort is to understand the mechanisms implicated in this pathological process …

Hepatocellular carcinoma (HCC) is the most frequent and deadly type of liver cancer. While
the underlying molecular mechanisms are poorly understood, it is documented that lncRNAs …

The intricate epigenetic landscape of hepatocellular carcinoma (HCC) is profoundly
influenced by alterations in DNA methylation patterns. Understanding these alterations is …