Advances in molecular diagnosis of tuberculosis

E MacLean, M Kohli, SF Weber, A Suresh… - Journal of clinical …, 2020 - Am Soc Microbiol
Molecular tests for tuberculosis (TB) have the potential to help reach the three million people
with TB who are undiagnosed or not reported each year and to improve the quality of care …

Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children

AW Kay, T Ness, SE Verkuijl, K Viney… - Cochrane Database …, 2022 - cochranelibrary.com
Background Every year, an estimated one million children and young adolescents become
ill with tuberculosis, and around 226,000 of those children die. Xpert MTB/RIF Ultra (Xpert …

[HTML][HTML] Reimagining the status quo: How close are we to rapid sputum-free tuberculosis diagnostics for all?

RR Nathavitharana, AL Garcia-Basteiro, M Ruhwald… - …, 2022 - thelancet.com
Rapid, accurate, sputum-free tests for tuberculosis (TB) triage and confirmation are urgently
needed to close the widening diagnostic gap. We summarise key technologies and review …

[HTML][HTML] Prevalence of bacteriologically confirmed pulmonary tuberculosis in South Africa, 2017–19: a multistage, cluster-based, cross-sectional survey

S Moyo, F Ismail, M Van der Walt, N Ismail… - The Lancet Infectious …, 2022 - thelancet.com
Background Tuberculosis remains an important clinical and public health issue in South
Africa, which has one of the highest tuberculosis burdens in the world. We aimed to estimate …

Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children

AW Kay, LG Fernández, Y Takwoingi… - Cochrane Database …, 2020 - cochranelibrary.com
Background Every year, at least one million children become ill with tuberculosis and
around 200,000 children die. Xpert MTB/RIF and Xpert Ultra are World Health Organization …

Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis

JS Zifodya, JS Kreniske, I Schiller… - Cochrane Database …, 2021 - cochranelibrary.com
Background Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert Ultra) are World Health
Organization (WHO)‐recommended rapid tests that simultaneously detect tuberculosis and …

HIV-Associated Tuberculosis

G Meintjes, G Maartens - New England Journal of Medicine, 2024 - Mass Medical Soc
Key Points HIV-Associated Tuberculosis Almost half of inpatients with human
immunodeficiency virus (HIV)–associated tuberculosis in countries with a high disease …

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin

GR Davies, M Chaplin, M De Vos… - Cochrane Database …, 2022 - cochranelibrary.com
Background The World Health Organization (WHO) End TB Strategy stresses universal
access to drug susceptibility testing (DST). DST determines whether Mycobacterium …

[HTML][HTML] Anaerobe-enriched gut microbiota predicts pro-inflammatory responses in pulmonary tuberculosis

CC Naidoo, GR Nyawo, I Sulaiman, BG Wu… - …, 2021 - thelancet.com
Background The relationship between tuberculosis (TB), one of the leading infectious
causes of death worldwide, and the microbiome, which is critical for health, is poorly …

[HTML][HTML] Evaluation of chest X-ray with automated interpretation algorithms for mass tuberculosis screening in prisons: a cross-sectional study

TR Soares, RD de Oliveira, YE Liu… - The Lancet Regional …, 2023 - thelancet.com
Summary Background The World Health Organization (WHO) recommends systematic
tuberculosis (TB) screening in prisons. Evidence is lacking for accurate and scalable …