Cardiovascular disease in diabetes, beyond glucose

RH Eckel, KE Bornfeldt, IJ Goldberg - Cell metabolism, 2021 - cell.com
Despite the decades-old knowledge that diabetes mellitus is a major risk factor for
cardiovascular disease, the reasons for this association are only partially understood. While …

High density lipoprotein cholesterol efflux capacity and atherosclerosis in cardiovascular disease: pathophysiological aspects and pharmacological perspectives

MP Adorni, N Ronda, F Bernini, F Zimetti - Cells, 2021 - mdpi.com
Over the years, the relationship between high-density lipoprotein (HDL) and atherosclerosis,
initially highlighted by the Framingham study, has been revealed to be extremely complex …

HDL functions—current status and future perspectives

Y Endo, M Fujita, K Ikewaki - Biomolecules, 2023 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of death in Western countries. A low
HDL-C is associated with the development of CVD. However, recent epidemiology studies …

High-density lipoprotein alterations in type 2 diabetes and obesity

D Denimal, S Monier, B Bouillet, B Vergès, L Duvillard - Metabolites, 2023 - mdpi.com
Alterations affecting high-density lipoproteins (HDLs) are one of the various abnormalities
observed in dyslipidemia in type 2 diabetes mellitus (T2DM) and obesity. Kinetic studies …

ApoA-I and diabetes

TW King, BJ Cochran, KA Rye - Arteriosclerosis, Thrombosis, and …, 2023 - Am Heart Assoc
ApoA-I—the main apolipoprotein constituent of the HDL (high-density lipoprotein) fraction of
human plasma—is of therapeutic interest because it has several cardioprotective functions …

Endothelial dysfunction in diabetes mellitus: new insights

M Dubsky, J Veleba, D Sojakova… - International Journal of …, 2023 - mdpi.com
Endothelial dysfunction (ED) is an important marker of future atherosclerosis and
cardiovascular disease, especially in people with diabetes. This article summarizes the …

[HTML][HTML] HDL functionality in type 1 and type 2 diabetes: new insights

MJ Chapman - Current Opinion in Endocrinology, Diabetes and …, 2022 - journals.lww.com
HDL functionality in type 1 and type 2 diabetes: new insight... : Current Opinion in
Endocrinology, Diabetes and Obesity HDL functionality in type 1 and type 2 diabetes: new …

High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank

Q Jin, ESH Lau, AO Luk, CHT Tam, R Ozaki… - Cardiovascular …, 2022 - Springer
Objective High-density lipoproteins (HDL) comprise particles of different size, density and
composition and their vasoprotective functions may differ. Diabetes modifies the composition …

Flipped C-terminal ends of apoA1 promote ABCA1-dependent cholesterol efflux by small HDLs

Y He, C Pavanello, PM Hutchins, C Tang… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Cholesterol efflux capacity (CEC) predicts cardiovascular disease
independently of high-density lipoprotein (HDL) cholesterol levels. Isolated small HDL …

Alterations of HDL's to piHDL's proteome in patients with chronic inflammatory diseases, and HDL-targeted therapies

V Vyletelová, M Nováková, Ľ Pašková - Pharmaceuticals, 2022 - mdpi.com
Chronic inflammatory diseases, such as rheumatoid arthritis, steatohepatitis, periodontitis,
chronic kidney disease, and others are associated with an increased risk of atherosclerotic …