Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

Purpose—The purpose of this statement is to review the literature on childhood stroke and to
provide recommendations for optimal diagnosis and treatment. This statement is intended …

With advances in brain imaging and completion of randomized clinical trials (RCTs) for
primary and secondary stroke prevention, the natural history of central nervous system …

Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle
cell disease (SCD). Patients may present with ACS or may develop this complication during …

Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …

Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity
and mortality. The pulmonary complications of SCD are of particular importance, as acute …

Neurologic complications are a major cause of morbidity and mortality in sickle cell disease
(SCD). In children with sickle cell anemia, routine use of transcranial Doppler screening …

Methods This narrative review was written using data drawn from a systematic literature
search last updated on June 24, 2019, from which 139 articles were analyzed in full text. For …

Hemorrhagic stroke accounts for approximately half of stroke in childhood. Unlike arterial
ischemic stroke, there are no consensus guidelines to assist in the evaluation and treatment …

Stroke is increasingly recognised as a cause of childhood disability and lifelong morbidity:
population-based estimates of the annual incidence of childhood stroke (ischaemic and …