Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death
E de Alteriis, F Cartenì, P Parascandola, J Serpa… - Cell Cycle, 2018 - Taylor & Francis
The mechanisms behind the Warburg effect in mammalian cells, as well as for the similar
Crabtree effect in the yeast Saccharomyces cerevisiae, are still a matter of debate: why do …
Crabtree effect in the yeast Saccharomyces cerevisiae, are still a matter of debate: why do …
[HTML][HTML] Cellular adaptation takes advantage of atavistic regression programs during carcinogenesis
D Gnocchi, D Nikolic, RR Paparella, C Sabbà… - Cancers, 2023 - mdpi.com
Simple Summary Cancer can be considered the epidemic of the third millennium, and recent
projections paint a worrying scenario for the coming decades. Knowledge about the causes …
projections paint a worrying scenario for the coming decades. Knowledge about the causes …
An enzyme‐coated metal–organic framework shell for synthetically adaptive cell survival
A bioactive synthetic porous shell was engineered to enable cells to survive in an
oligotrophic environment. Eukaryotic cells (yeast) were firstly coated with a β‐galactosidase …
oligotrophic environment. Eukaryotic cells (yeast) were firstly coated with a β‐galactosidase …
Ultrahigh performance liquid chromatography− tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites
Quantification of metabolites is of pivotal relevance in biology, where it complements more
established omics techniques such as transcriptomics and proteomics. Here, we present a …
established omics techniques such as transcriptomics and proteomics. Here, we present a …
Transcriptional regulation is insufficient to explain substrate‐induced flux changes in Bacillus subtilis
One of the key ways in which microbes are thought to regulate their metabolism is by
modulating the availability of enzymes through transcriptional regulation. However, the …
modulating the availability of enzymes through transcriptional regulation. However, the …
Proteomic and physiological analyses of wheat seeds exposed to copper and iron nanoparticles
To elucidate the role of Cu and Fe NPs on the yield of wheat varieties, a gel-free proteomic
technique was used. NPs were synthesized and characterized through zeta potential, EDX …
technique was used. NPs were synthesized and characterized through zeta potential, EDX …
[HTML][HTML] Metabolic effects of influenza virus infection in cultured animal cells: Intra-and extracellular metabolite profiling
Background Many details in cell culture-derived influenza vaccine production are still poorly
understood and approaches for process optimization mainly remain empirical. More insights …
understood and approaches for process optimization mainly remain empirical. More insights …
[HTML][HTML] Full humanization of the glycolytic pathway in Saccharomyces cerevisiae
FJ Boonekamp, E Knibbe, MA Vieira-Lara, M Wijsman… - Cell Reports, 2022 - cell.com
Although transplantation of single genes in yeast plays a key role in elucidating gene
functionality in metazoans, technical challenges hamper humanization of full pathways and …
functionality in metazoans, technical challenges hamper humanization of full pathways and …
Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity
What is the relationship between enzymes and metabolites, the two major constituents of
metabolic networks? We propose three alternative relationships between enzyme capacity …
metabolic networks? We propose three alternative relationships between enzyme capacity …
Measuring enzyme activities under standardized in vivo‐like conditions for systems biology
Realistic quantitative models require data from many laboratories. Therefore,
standardization of experimental systems and assay conditions is crucial. Moreover …
standardization of experimental systems and assay conditions is crucial. Moreover …