The mutagenic action of N-ethyl-N-nitrosourea in the mouse.
JK Noveroske, JS Weber, MJ Justice - Mammalian genome, 2000 - search.ebscohost.com
This article focuses on mutagenic action of N-ethyl-N-nitrosourea. N-ethyl-N-nitrosourea
(ENU) has become one of the most powerful tools in mammalian genetics. It has the highest …
(ENU) has become one of the most powerful tools in mammalian genetics. It has the highest …
Development of the adverse outcome pathway “alkylation of DNA in male premeiotic germ cells leading to heritable mutations” using the OECD's users' handbook …
CL Yauk, IB Lambert, ME Meek… - Environmental and …, 2015 - Wiley Online Library
The Organisation for Economic Cooperation and Development's (OECD) Adverse Outcome
Pathway (AOP) programme aims to develop a knowledgebase of all known pathways of …
Pathway (AOP) programme aims to develop a knowledgebase of all known pathways of …
Heritable and cancer risks of exposures to anticancer drugs: inter-species comparisons of covalent deoxyribonucleic acid-binding agents
EW Vogel, A Barbin, MJM Nivard, HF Stack… - Mutation Research …, 1998 - Elsevier
In the past years, several methodologies were developed for potency ranking of genotoxic
carcinogens and germ cell mutagens. In this paper, we analyzed six sub-classes of covalent …
carcinogens and germ cell mutagens. In this paper, we analyzed six sub-classes of covalent …
Relationships between cisplatin-induced adducts and DNA strand-breaks, mutation and recombination in vivo in somatic cells of Drosophila melanogaster, under …
DG Sar, L Aguado, MM Bayón, MA Comendador… - … /Genetic Toxicology and …, 2012 - Elsevier
Cisplatin is a chemotherapeutic drug widely used in the treatment of several tumours, but
this chemotherapy presents problems in terms of side-effects and patient resistance. The …
this chemotherapy presents problems in terms of side-effects and patient resistance. The …
[HTML][HTML] Braf mutations initiate the development of rat gliomas induced by postnatal exposure to N-Ethyl-N-nitrosourea
A single dose of N-ethyl-N-nitrosourea (ENU) during late prenatal or early postnatal
development induces a high incidence of malignant schwannomas and gliomas in rats …
development induces a high incidence of malignant schwannomas and gliomas in rats …
In vivo repair of ENU-induced oxygen alkylation damage by the nucleotide excision repair mechanism in Drosophila melanogaster
L Tosal, MA Comendador, LM Sierra - Molecular Genetics and Genomics, 2001 - Springer
DNA damage caused by oxygen alkylation of bases (mainly at O 6-G, O 4-T and O 2-T
positions in DNA) has been correlated with the mutagenic and carcinogenic potency of …
positions in DNA) has been correlated with the mutagenic and carcinogenic potency of …
Adaptive response to alkylating agents in the Drosophila sex-linked recessive lethal assay
N Savina, O Dalivelya, T Kuzhir - Mutation Research/Genetic Toxicology …, 2003 - Elsevier
The adaptive response to alkylating agents was studied in Drosophila assays under various
treatment procedures. Pre-treatment of males as well as treatment of females with low doses …
treatment procedures. Pre-treatment of males as well as treatment of females with low doses …
Female germ cell mutagenicity of model chemicals in Drosophila melanogaster: mechanistic information and analysis of repair systems
J Hernando, L Álvarez, JA Ferreiro, I Sancho… - Mutation Research …, 2004 - Elsevier
In spite of differences between female and male germ cells, and although both of them
contribute to the gene pool of future generations, most germ cell mutagenicity studies in …
contribute to the gene pool of future generations, most germ cell mutagenicity studies in …
Genetic damage by bifunctional agents in repair-active pre-meiotic stages of Drosophila males
JPH Wijen, MJM Nivard, EW Vogel - Mutation Research/Fundamental and …, 2001 - Elsevier
Most of our understanding of germline mutagenesis in Drosophila is based on the DNA
repair-inactive, haploid post-meiotic stages. The diploid, repair-active pre-meiotic stages are …
repair-inactive, haploid post-meiotic stages. The diploid, repair-active pre-meiotic stages are …
The mus308 locus of Drosophila melanogaster is implicated in the bypass of ENU-induced O-alkylpyrimidine adducts
L Tosal, MA Comendador, LM Sierra - Molecular and General Genetics …, 2000 - Springer
The mus308 locus of D. melanogaster was originally characterized by virtue of a mutant
phenotype that resulted in specific hypersensitivity to cross-linking agents. However, the …
phenotype that resulted in specific hypersensitivity to cross-linking agents. However, the …