The physiology of bilirubin: health and disease equilibrium
L Vitek, TD Hinds, DE Stec, C Tiribelli - Trends in molecular medicine, 2023 - cell.com
Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …
[HTML][HTML] Aspartate aminotransferase and cardiovascular disease—a narrative review
G Ndrepepa - Journal of Laboratory and Precision Medicine, 2021 - jlpm.amegroups.org
This narrative review summarized the existing knowledge on the association between
aspartate aminotransferase (AST) and cardiovascular disease (CVD). AST plays a key role …
aspartate aminotransferase (AST) and cardiovascular disease (CVD). AST plays a key role …
A novel perspective on the biology of bilirubin in health and disease
S Gazzin, L Vitek, J Watchko, SM Shapiro… - Trends in molecular …, 2016 - cell.com
Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …
Elevated liver enzymes and cardiovascular mortality: a systematic review and dose–response meta-analysis of more than one million participants
Gamma glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate
aminotransferase (AST), and alkaline phosphatase (ALP) are commonly used liver function …
aminotransferase (AST), and alkaline phosphatase (ALP) are commonly used liver function …
Bilirubin nanoparticles protect against cardiac ischemia/reperfusion injury in mice
W Ai, S Bae, Q Ke, S Su, R Li, Y Chen… - Journal of the …, 2021 - Am Heart Assoc
Background Ischemia/reperfusion (I/R) injury causes overproduction of reactive oxygen
species, which are the major culprits of oxidative stress that leads to inflammation …
species, which are the major culprits of oxidative stress that leads to inflammation …
Increased uric acid, gamma-glutamyl transpeptidase and alkaline phosphatase in early-pregnancy associated with the development of gestational hypertension and …
Y Chen, W Ou, D Lin, M Lin, X Huang, S Ni… - Frontiers in …, 2021 - frontiersin.org
Background: Previous studies have reported that biomarkers of liver injury and renal
dysfunction were associated with hypertensive disorders of pregnancy (HDP). However, the …
dysfunction were associated with hypertensive disorders of pregnancy (HDP). However, the …
Bilirubin as a predictor of diseases of civilization. Is it time to establish decision limits for serum bilirubin concentrations?
L Vitek - Archives of biochemistry and biophysics, 2019 - Elsevier
Bilirubin is among the most potent of the endogenous antioxidants. Data developed over the
last three decades have convincingly demonstrated the protective effects of mildly elevated …
last three decades have convincingly demonstrated the protective effects of mildly elevated …
Serum bilirubin levels in overweight and obese individuals: the importance of anti-inflammatory and antioxidant responses
L Žiberna, Z Jenko-Pražnikar, A Petelin - Antioxidants, 2021 - mdpi.com
Obesity is a chronic condition involving low-grade inflammation and increased oxidative
stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially …
stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially …
Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea
Bilirubin, a potentially toxic catabolite of heme and indicator of hepatobiliary insufficiency,
exhibits potent cardiac and vascular protective properties. Individuals with Gilbert's …
exhibits potent cardiac and vascular protective properties. Individuals with Gilbert's …
[HTML][HTML] Alanine aminotransferase—a marker of cardiovascular risk at high and low activity levels
G Ndrepepa, A Kastrati - Journal of Laboratory and Precision …, 2019 - jlpm.amegroups.org
Alanine aminotransferase (ALT) plays a crucial role in amino acid metabolism and
gluconeogenesis. Serum ALT activity is a reliable marker of liver disease and general …
gluconeogenesis. Serum ALT activity is a reliable marker of liver disease and general …