Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

The immune system functions in a sexually dimorphic manner, with females exhibiting more
robust immune responses than males. However, how female sex hormones affect immune …

The immune system protects the body against harm by inducing inflammation. During the
immune response, cells of the immune system get activated, divided and differentiated in …

Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.
However, cholesterol metabolism as a key component of this regulation remains largely …

Abstract Background 27-hydroxycholesterol (HC) and 25-HC were identified as endogenous
selective estrogen receptor modulators (SERMs) and estrogen receptor (ER) modulators …

The field of cardio-oncology has emerged in response to the increased risk of
cardiovascular disease (CVD) in patients with cancer. However, recent studies suggest a …

Oxysterols are cholesterol metabolites generated in the liver and other peripheral tissues as
a mechanism of removing excess cholesterol. Oxysterols have a wide range of biological …

Delaying and even reversing ageing is a major public health challenge with a tremendous
potential to postpone a plethora of diseases including cancer, metabolic syndromes and …

Objective Adaptive rewiring of cancer energy metabolism has received increasing attention.
By binding with LDLs, LDLRs make most of the circulating cholesterol available for cells to …

27-Hydroxycholesterol (27-HC) is the most abundant oxysterol that increases the risk of
breast cancer progression. However, little is known about epigenetic regulation of 27-HC …