Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

Cell death provides host defense and maintains homeostasis. Zα-containing molecules are
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …

Inflammasomes are molecular platforms that assemble upon sensing various intracellular
stimuli. Inflammasome assembly leads to activation of caspase 1, thereby promoting the …

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Inflammasomes are large intracellular multi-protein signalling complexes that are formed in
the cytosolic compartment as an inflammatory immune response to endogenous danger …

The intestinal epithelial lining, together with factors secreted from it, forms a barrier that
separates the host from the environment. In pathologic conditions, the permeability of the …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Quantitative and qualitative aspects of nutrition have a profound effect on leukocytes and
thereby affect proinflammatory carcinogenic effects or anticancer immune responses. As a …

AIM2 is a cytosolic innate immune receptor which recognizes double‐stranded DNA
(dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of …