Insulin therapy development beyond 100 years

PD Home, R Mehta - The Lancet Diabetes & Endocrinology, 2021 - thelancet.com
The first insulin preparation capable of consistently lowering blood glucose was developed
in 1921. But 100 years later, blood glucose control with insulin in people with diabetes is …

Progress in islet transplantation is more important than ever

SR Bornstein, B Ludwig, C Steenblock - Nature Reviews Endocrinology, 2022 - nature.com
Progress in islet transplantation is more important than ever | Nature Reviews Endocrinology
Skip to main content Thank you for visiting nature.com. You are using a browser version with …

Mesenchymal stem cell‐laden composite β cell porous microgel for diabetes treatment

J Sun, J Li, Z Huan, SJ Pandol, D Liu… - Advanced Functional …, 2023 - Wiley Online Library
Type 1 diabetes mellitus is a chronic metabolic condition characterized by the autoimmune
damage of pancreatic β cells. As an alternative to continuous exogenous insulin …

[HTML][HTML] Engineering a modular double-transmembrane synthetic receptor system for customizing cellular programs

J Zhou, Q Ge, D Wang, Q Guo, Y Tao - Cell Reports, 2023 - cell.com
Implementation of designer receptors in engineered cells confers them to sense a particular
physiological or disease state and respond with user-defined programs. To expand the …

Targeting β cells with cathelicidin nanomedicines improves insulin function and pancreas regeneration in type 1 diabetic rats

C Cristelo, R Nunes, S Pinto, JM Marques… - ACS Pharmacology & …, 2023 - ACS Publications
Type 1 diabetes (T1D) is an incurable condition with an increasing incidence worldwide, in
which the hallmark is the autoimmune destruction of pancreatic insulin-producing β cells …

Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space

GS Chendke, BN Kharbikar, S Ashe… - Bioengineering & …, 2023 - Wiley Online Library
Beta cell replacement therapy (BCRT) for patients with type 1 diabetes (T1D) improves
blood glucose regulation by replenishing the endogenous beta cells destroyed by …

[HTML][HTML] Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes

T Kitamoto, YK Lee, N Sultana, H Watanabe… - Molecular …, 2022 - Elsevier
Objective Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment.
Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose …

Futuristic opportunities for pretreatment processes in biofuel production from microalgae

CH Tan, SS Low, WY Cheah, J Singh, WS Chai… - GCB …, 2024 - Wiley Online Library
Microalgal biofuel is a promising solution to replace fossil fuel as a renewable and
environmental‐friendly energy source, thereby contributing to the United Nations (UN) …

An Autoclavable and Transparent Thermal Cutter for Reliably Sealing Wet Nanofibrous Membranes

C Fang, Y Gu, H Shi, J Hu, Y Wang, M Pan, J Feng… - Nano Letters, 2024 - ACS Publications
Sealing wet porous membranes is a major challenge when fabricating cell encapsulation
devices. Herein, we report the development of an A utoclavable T ransparent T hermal C …

Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation

Q Fu, Y Qian, H Jiang, Y He, H Dai, Y Chen… - Science China Life …, 2024 - Springer
During the pathogenesis of type 1 diabetes (T1D) and type 2 diabetes (T2D), pancreatic
islets, especially the β cells, face significant challenges. These insulin-producing cells adopt …