Altered GABA signaling in early life epilepsies
SW Briggs, AS Galanopoulou - Neural plasticity, 2011 - Wiley Online Library
The incidence of seizures is particularly high in the early ages of life. The immaturity of
inhibitory systems, such as GABA, during normal brain development and its further …
inhibitory systems, such as GABA, during normal brain development and its further …
Ionic and synaptic mechanisms of seizure generation and epileptogenesis
The biophysical mechanisms underlying epileptogenesis and the generation of seizures
remain to be better understood. Among many factors triggering epileptogenesis are …
remain to be better understood. Among many factors triggering epileptogenesis are …
Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation
Activation of γ-aminobutyric acid (GABA A) receptors have been associated with the onset of
epileptiform events. To investigate if a causal relationship exists between GABA A receptor …
epileptiform events. To investigate if a causal relationship exists between GABA A receptor …
TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various …
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious
long-term disability, often leads to the development of epilepsy. Patients who develop post …
long-term disability, often leads to the development of epilepsy. Patients who develop post …
Sleep, oscillations, and epilepsy
Sleep and wake are defined through physiological and behavioral criteria and can be
typically separated into non‐rapid eye movement (NREM) sleep stages N1, N2, and N3 …
typically separated into non‐rapid eye movement (NREM) sleep stages N1, N2, and N3 …
Loss of CLOCK results in dysfunction of brain circuits underlying focal epilepsy
Because molecular mechanisms underlying refractory focal epilepsy are poorly defined, we
performed transcriptome analysis on human epileptogenic tissue. Compared with controls …
performed transcriptome analysis on human epileptogenic tissue. Compared with controls …
Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome
Dravet syndrome (DS) is one of the most severe childhood epilepsies, characterized by
intractable seizures and comorbidities including cognitive and social dysfunction and high …
intractable seizures and comorbidities including cognitive and social dysfunction and high …
Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization
SM Wilson, W Xiong, Y Wang, X Ping, JD Head… - Neuroscience, 2012 - Elsevier
Epileptogenesis following traumatic brain injury (TBI) is likely due to a combination of
increased excitability, disinhibition, and increased excitatory connectivity via aberrant axon …
increased excitability, disinhibition, and increased excitatory connectivity via aberrant axon …
Does time heal all wounds? Experimental diffuse traumatic brain injury results in persisting histopathology in the thalamus
Background Thalamic dysfunction has been implicated in overall chronic neurological
dysfunction after traumatic brain injury (TBI), however little is known about the underlying …
dysfunction after traumatic brain injury (TBI), however little is known about the underlying …
A potential role for glia‐derived extracellular matrix remodeling in postinjury epilepsy
SY Kim, BE Porter, A Friedman… - Journal of neuroscience …, 2016 - Wiley Online Library
Head trauma and vascular injuries are known risk factors for acquired epilepsy. The
sequence of events that lead from the initial injury to the development of epilepsy involves …
sequence of events that lead from the initial injury to the development of epilepsy involves …