▪ Abstract Phototransduction is the process by which a photon of light captured by a
molecule of visual pigment generates an electrical response in a photoreceptor cell …

Genetic experiments have recently been used to identify a family of 'regulator of G-protein
signaling'(RGS) proteins, which downregulate signaling by heterotrimeric G proteins. The …

Publisher Summary This chapter discusses the research that has characterized the G-
protein cascade of transduction in vertebrate photoreceptors, with particular emphasis on …

Histone acetyltransferases and deacetylases can be targeted to promoters to activate or
repress genes. For example, the histone acetyltransferase GCN5 is part of a yeast …

The crystal structure of transducin's βγ subunits complexed with phosducin, which regulates
G t βγ activity, has been solved to 2.4 Å resolution. Phosducin has two domains that wrap …

Reactive oxygen species (ROS) have been identified as central mediators in certain
signalling events,,,. In the heart, ROS have important functions in ischaemia/reperfusion …

Kinases play central roles in signaling cascades, relaying information from the outside to the
inside of mammalian cells. De novo designed protein switches capable of interfacing with …

Phosducin is a photoreceptor-specific protein known to interact with the βγ subunits of G
proteins. In pursuit of the function of phosducin, we tested the hypothesis that it regulates the …

Members of the phosducin gene family were initially proposed to act as down-regulators of
G protein signaling by binding G protein βγ dimers (Gβγ) and inhibiting their ability to interact …

Visual signal transduction is a nearly noise-free process that is exquisitely well regulated
over a wide dynamic range of light intensity. A key component in dark/light adaptation is …