Emerging frontiers of deep eutectic solvents in drug discovery and drug delivery systems

MH Zainal-Abidin, M Hayyan, GC Ngoh… - Journal of Controlled …, 2019 - Elsevier
The applications of eutectic systems, including deep eutectic solvents (DESs), in diverse
sectors have drawn significant interest from researchers, academicians, engineers, medical …

Innovative mucosal vaccine formulations against influenza A virus infections

C Calzas, C Chevalier - Frontiers in immunology, 2019 - frontiersin.org
Despite efforts made to develop efficient preventive strategies, infections with influenza A
viruses (IAV) continue to cause serious clinical and economic problems. Current licensed …

A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface

S Bangaru, S Lang, M Schotsaert, HA Vanderven… - Cell, 2019 - cell.com
Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …

Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans

HL Dugan, JJ Guthmiller, P Arevalo, M Huang… - Science translational …, 2020 - science.org
Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a
result, preexisting influenza-specific memory B cells can dominate the response after …

Novel correlates of protection against pandemic H1N1 influenza A virus infection

S Ng, R Nachbagauer, A Balmaseda, D Stadlbauer… - Nature medicine, 2019 - nature.com
Influenza viruses remain a severe threat to human health, causing up to 650,000 deaths
annually,. Seasonal influenza virus vaccines can prevent infection, but are rendered …

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

W He, CJ Chen, CE Mullarkey, JR Hamilton… - Nature …, 2017 - nature.com
The aim of candidate universal influenza vaccines is to provide broad protection against
influenza A and B viruses. Studies have demonstrated that broadly reactive antibodies …

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

W He, GS Tan, CE Mullarkey, AJ Lee… - Proceedings of the …, 2016 - National Acad Sciences
The generation of strain-specific neutralizing antibodies against influenza A virus is known
to confer potent protection against homologous infections. The majority of these antibodies …

Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms

M Ramberger, A Berretta, JMM Tan, B Sun, S Michael… - Brain, 2020 - academic.oup.com
Autoantibodies against leucine-rich glioma inactivated 1 (LGI1) are found in patients with
limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal …

IgA potentiates NETosis in response to viral infection

HD Stacey, D Golubeva, A Posca… - Proceedings of the …, 2021 - National Acad Sciences
IgA is the second most abundant antibody present in circulation and is enriched at mucosal
surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens …

Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact

PE Leon, W He, CE Mullarkey… - Proceedings of the …, 2016 - National Acad Sciences
Influenza virus strain-specific monoclonal antibodies (mAbs) provide protection independent
of Fc gamma receptor (FcγR) engagement. In contrast, optimal in vivo protection achieved …