Emerging frontiers of deep eutectic solvents in drug discovery and drug delivery systems
The applications of eutectic systems, including deep eutectic solvents (DESs), in diverse
sectors have drawn significant interest from researchers, academicians, engineers, medical …
sectors have drawn significant interest from researchers, academicians, engineers, medical …
Innovative mucosal vaccine formulations against influenza A virus infections
C Calzas, C Chevalier - Frontiers in immunology, 2019 - frontiersin.org
Despite efforts made to develop efficient preventive strategies, infections with influenza A
viruses (IAV) continue to cause serious clinical and economic problems. Current licensed …
viruses (IAV) continue to cause serious clinical and economic problems. Current licensed …
A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface
S Bangaru, S Lang, M Schotsaert, HA Vanderven… - Cell, 2019 - cell.com
Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans
HL Dugan, JJ Guthmiller, P Arevalo, M Huang… - Science translational …, 2020 - science.org
Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a
result, preexisting influenza-specific memory B cells can dominate the response after …
result, preexisting influenza-specific memory B cells can dominate the response after …
Novel correlates of protection against pandemic H1N1 influenza A virus infection
S Ng, R Nachbagauer, A Balmaseda, D Stadlbauer… - Nature medicine, 2019 - nature.com
Influenza viruses remain a severe threat to human health, causing up to 650,000 deaths
annually,. Seasonal influenza virus vaccines can prevent infection, but are rendered …
annually,. Seasonal influenza virus vaccines can prevent infection, but are rendered …
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
The aim of candidate universal influenza vaccines is to provide broad protection against
influenza A and B viruses. Studies have demonstrated that broadly reactive antibodies …
influenza A and B viruses. Studies have demonstrated that broadly reactive antibodies …
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus
The generation of strain-specific neutralizing antibodies against influenza A virus is known
to confer potent protection against homologous infections. The majority of these antibodies …
to confer potent protection against homologous infections. The majority of these antibodies …
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
Autoantibodies against leucine-rich glioma inactivated 1 (LGI1) are found in patients with
limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal …
limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal …
IgA potentiates NETosis in response to viral infection
HD Stacey, D Golubeva, A Posca… - Proceedings of the …, 2021 - National Acad Sciences
IgA is the second most abundant antibody present in circulation and is enriched at mucosal
surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens …
surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens …
Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact
PE Leon, W He, CE Mullarkey… - Proceedings of the …, 2016 - National Acad Sciences
Influenza virus strain-specific monoclonal antibodies (mAbs) provide protection independent
of Fc gamma receptor (FcγR) engagement. In contrast, optimal in vivo protection achieved …
of Fc gamma receptor (FcγR) engagement. In contrast, optimal in vivo protection achieved …