Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-
positive infections and, importantly, multidrug-resistant tuberculosis. Among various …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

Natural berberine-derived azolyl ethanols as new structural antibacterial agents were
designed and synthesized for fighting with dreadful bacterial resistance. Partial target …

The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus
burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a …

Cationic amphiphiles derived from aminoglycosides (AGs) have been shown to exhibit
enhanced antimicrobial activity. Through the attachment of hydrophobic residues such as …

Local targeted treatment of bone and joint infections using antibiotic-containing carriers is a
common practice today. A recently FDA approved biphasic calcium sulphate/hydroxyapatite …

Ribosomes, which synthesize proteins, are critical organelles for the survival and growth of
bacteria. About 60% of approved antibiotics discovered so far combat pathogenic bacteria …

Since the discovery of the first aminoglycoside (AG), streptomycin, in 1943, these broad-
spectrum antibiotics have been extensively used for the treatment of Gram-negative and …

Aminoglycosides containing a 2-deoxystreptamine core (AGs) represent a large family of
antibiotics that target the ribosome. These compounds promote miscoding, inhibit …

Central nervous system infections can be complications of neurosurgical procedures or can
occur spontaneously, and occasionally lead to devastating neurological complications …