Structure, regulation, and functional diversity of microvilli on the apical domain of epithelial cells
Microvilli are actin-based structures found on the apical aspect of many epithelial cells. In
this review, we discuss different types of microvilli, as well as comparisons with actin-based …
this review, we discuss different types of microvilli, as well as comparisons with actin-based …
Various themes of myosin regulation
SM Heissler, JR Sellers - Journal of molecular biology, 2016 - Elsevier
Members of the myosin superfamily are actin-based molecular motors that are
indispensable for cellular homeostasis. The vast functional and structural diversity of …
indispensable for cellular homeostasis. The vast functional and structural diversity of …
Autoinhibition and activation mechanisms revealed by the triangular-shaped structure of myosin Va
As the prototype of unconventional myosin motor family, myosin Va (MyoVa) transport
cellular cargos along actin filaments in diverse cellular processes. The off-duty MyoVa …
cellular cargos along actin filaments in diverse cellular processes. The off-duty MyoVa …
Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction
M Grati, B Kachar - Proceedings of the National Academy of …, 2011 - National Acad Sciences
In the most accepted model for hair cell mechanotransduction, a cluster of myosin motors
located at the stereocilia upper tip-link density (UTLD) keeps the tip-link under tension at …
located at the stereocilia upper tip-link density (UTLD) keeps the tip-link under tension at …
The myosin family of mechanoenzymes: from mechanisms to therapeutic approaches
DV Trivedi, S Nag, A Spudich… - Annual review of …, 2020 - annualreviews.org
Myosins are among the most fascinating enzymes in biology. As extremely allosteric
chemomechanical molecular machines, myosins are involved in myriad pivotal cellular …
chemomechanical molecular machines, myosins are involved in myriad pivotal cellular …
Myosin-X: a MyTH-FERM myosin at the tips of filopodia
ML Kerber, RE Cheney - Journal of cell science, 2011 - journals.biologists.com
Myosin-X (Myo10) is an unconventional myosin with MyTH4-FERM domains that is best
known for its striking localization to the tips of filopodia and its ability to induce filopodia …
known for its striking localization to the tips of filopodia and its ability to induce filopodia …
Principles of unconventional myosin function and targeting
MA Hartman, D Finan… - Annual review of cell …, 2011 - annualreviews.org
Unconventional myosins are a superfamily of actin-based motors implicated in diverse
cellular processes. In recent years, much progress has been made in describing their …
cellular processes. In recent years, much progress has been made in describing their …
Kinetic adaptations of myosins for their diverse cellular functions
SM Heissler, JR Sellers - Traffic, 2016 - Wiley Online Library
Members of the myosin superfamily are involved in all aspects of eukaryotic life. Their
function ranges from the transport of organelles and cargos to the generation of membrane …
function ranges from the transport of organelles and cargos to the generation of membrane …
Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals
Electron microscope studies have shown that the switched-off state of myosin II in muscle
involves intramolecular interaction between the two heads of myosin and between one head …
involves intramolecular interaction between the two heads of myosin and between one head …
The myosin X motor is optimized for movement on actin bundles
V Ropars, Z Yang, T Isabet, F Blanc, K Zhou… - Nature …, 2016 - nature.com
Myosin X has features not found in other myosins. Its structure must underlie its unique
ability to generate filopodia, which are essential for neuritogenesis, wound healing, cancer …
ability to generate filopodia, which are essential for neuritogenesis, wound healing, cancer …