Molecular regulation of autophagy machinery by mTOR‐dependent and‐independent pathways

MAA Al‐Bari, P Xu - Annals of the New York Academy of …, 2020 - Wiley Online Library
Macroautophagy is a lysosomal degradative pathway or recycling process that maintains
cellular homeostasis. This autophagy involves a series of sequential processing events …

Salivary gland function, development, and regeneration

AM Chibly, MH Aure, VN Patel… - Physiological …, 2022 - journals.physiology.org
Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

TRPC channels: Structure, function, regulation and recent advances in small molecular probes

H Wang, X Cheng, J Tian, Y Xiao, T Tian, F Xu… - Pharmacology & …, 2020 - Elsevier
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces

IS Ambudkar, LB de Souza, HL Ong - Cell calcium, 2017 - Elsevier
Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …

STIMulating store-operated Ca2+ entry

MD Cahalan - Nature cell biology, 2009 - nature.com
Calcium influx through plasma membrane store-operated Ca2+ (SOC) channels is triggered
when the endoplasmic reticulum (ER) Ca2+ store is depleted—a homeostatic Ca2+ …

Activation and regulation of store‐operated calcium entry

JT Smyth, SY Hwang, T Tomita… - Journal of cellular …, 2010 - Wiley Online Library
Introduction• I CRAC• Orais• STIM1• STIM2• STIM1, STIM2 and Ca2+ oscillations• TRPCs
and SOCE• Conclusions The process of store‐operated Ca2+ entry (SOCE), whereby Ca2+ …

Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions

KT Cheng, X Liu, HL Ong, W Swaim, IS Ambudkar - PLoS biology, 2011 - journals.plos.org
Store-operated Ca2+ entry (SOCE) has been associated with two types of channels: CRAC
channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and …

ORAI1 and STIM1 deficiency in human and mice: roles of store‐operated Ca2+ entry in the immune system and beyond

S Feske - Immunological reviews, 2009 - Wiley Online Library
Store‐operated Ca2+ entry (SOCE) is a mechanism used by many cells types including
lymphocytes and other immune cells to increase intracellular Ca2+ concentrations to initiate …

Contribution and regulation of TRPC channels in store-operated Ca2+ entry

KT Cheng, HL Ong, X Liu, IS Ambudkar - Current topics in membranes, 2013 - Elsevier
Store-operated calcium entry (SOCE) is activated in response to depletion of the
endoplasmic reticulum-Ca 2+ stores following stimulation of plasma membrane receptors …

Store-operated calcium channel complex in postsynaptic spines: a new therapeutic target for Alzheimer's disease treatment

H Zhang, S Sun, L Wu, E Pchitskaya… - Journal of …, 2016 - Soc Neuroscience
Mushroom dendritic spine structures are essential for memory storage and the loss of
mushroom spines may explain memory defects in aging and Alzheimer9s disease (AD). The …