Human physiological functions are regulated across many orders of magnitude in space and
time. Integrating the information and dynamics from one scale to another is critical for the …

This article reviews the current knowledge and recent advancements in computational
modeling of the cell cycle. It offers a comparative analysis of various modeling paradigms …

We propose a protein interaction network for the regulation of DNA synthesis and mitosis
that emphasizes the universality of the regulatory system among eukaryotic cells. The …

Activation of cyclin B1–cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback
loop at the end of G2, is the key event that initiates mitotic entry. In metaphase, anaphase …

The fruit is a hierarchically organized organ composed of cells from different tissues. Its
quality, defined by traits such as fruit size and composition, is the result of a complex chain of …

One of the early success stories of computational systems biology was the work done on cell-
cycle regulation. The earliest mathematical descriptions of cell-cycle control evolved into …

Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions.
Whenever biological parameters or external conditions change such that a threshold is …

Few of> 150 published cell cycle modeling efforts use significant levels of data for tuning
and validation. This reflects the difficultly to generate correlated quantitative data, and it …

Understanding what determines the size and composition of fruit, grain and seed in
response to the environment and genotype is challenging, as these traits result from several …

Abstract Background and Aims The Arabidopsis thaliana root is a key experimental system
in developmental biology. Despite its importance, we are still lacking an objective and …