SGLT2 inhibition via empagliflozin improves endothelial function and reduces mitochondrial oxidative stress: insights from frail hypertensive and diabetic patients

P Mone, F Varzideh, SS Jankauskas, A Pansini… - …, 2022 - Am Heart Assoc
Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …

The outcome of frailty in older people with diabetes as a function of glycaemic control and hypoglycaemic therapy: a review

GL Keegan, N Bhardwaj… - Expert Review of …, 2023 - Taylor & Francis
Introduction Frailty is an emerging and newly recognized complication of diabetes in older
people. However, frailty is not thoroughly investigated in diabetes outcome studies. Areas …

Cysteine and methionine oxidation in thrombotic disorders

M Yang, BC Smith - Current Opinion in Chemical Biology, 2023 - Elsevier
Thrombosis is the leading cause of death in many diseased conditions. Oxidative stress is
characteristic of these conditions. Yet, the mechanisms through which oxidants become …

Potential Therapeutic Properties of the Leaf of Cydonia Oblonga Mill. Based on Mineral and Organic Profiles

DM Ferreira, NM de Oliveira, L Lopes, J Machado… - Plants, 2022 - mdpi.com
Leaf extract of Cydonia Oblonga Mill. is interesting for further exploration of the potential of
its substrates for therapeutic supplements. Quantitative and qualitative analyses were …

[HTML][HTML] Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation

J Wittig, MK Drekolia, A Kyselova, FD Lagos… - Redox biology, 2023 - Elsevier
Tissue factor pathway inhibitor (TFPI) is an important regulator of coagulation and a link
between inflammation and thrombosis. Here we investigated whether endothelial cell-driven …

Analysis of thrombosis formation and growth using microfluidic chips and multiphase computational fluid dynamics

DH Ham, JS Choi, PH Jeong, JH Kim… - BioChip Journal, 2023 - Springer
Thrombosis is a vascular disease associated with severe risks such as heart attack and
stroke. Extensive research has been conducted worldwide to identify the underlying causes …

Redox mechanisms of platelet activation in aging

SX Gu, S Dayal - Antioxidants, 2022 - mdpi.com
Aging is intrinsically linked with physiologic decline and is a major risk factor for a broad
range of diseases. The deleterious effects of advancing age on the vascular system are …

Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial

JA Schults, ER Young, N Marsh, E Larsen… - Journal of Intensive …, 2024 - Springer
Abstract Objectives Arterial catheters (ACs) are critical for haemodynamic monitoring and
blood sampling but are prone to complications. We investigated the incidence and risk …

Targeting Cysteine Oxidation in Thrombotic Disorders

M Yang, RL Silverstein - Antioxidants, 2024 - mdpi.com
Oxidative stress increases the risk for clinically significant thrombotic events, yet the
mechanisms by which oxidants become prothrombotic are unclear. In this review, we …

Influence of diabetes on the risk of deep vein thrombosis of patients after total knee arthroplasty: a meta-analysis

J An, L Han, X Ma, Y Chang, C Zhang - Journal of Orthopaedic Surgery …, 2024 - Springer
Background Previous studies evaluating the influence of diabetes on the risk of deep vein
thrombosis (DVT) after total knee arthroplasty (TKA) showed inconsistent results. The aim of …