[HTML][HTML] Lyme borreliosis

AC Steere, F Strle, GP Wormser, LT Hu… - Nature reviews Disease …, 2016 - nature.com
Lyme borreliosis is a tick-borne disease that predominantly occurs in temperate regions of
the northern hemisphere and is primarily caused by the bacterium Borrelia burgdorferi in …

Lyme borreliosis–from tick bite to diagnosis and treatment

G Stanek, F Strle - FEMS microbiology reviews, 2018 - academic.oup.com
Lyme borreliosis is caused by certain genospecies of the Borrelia burgdorferi sensu lato
complex, which are transmitted by hard ticks of the genus Ixodes. The most common clinical …

Diagnosis and Treatment of Lyme Carditis: JACC Review Topic of the Week

C Yeung, A Baranchuk - Journal of the American College of Cardiology, 2019 - jacc.org
The incidence of Lyme disease, a tick-borne bacterial infection, is dramatically increasing in
North America. The diagnosis of Lyme carditis (LC), an early disseminated manifestation of …

Lyme borreliosis: diagnosis and management

BJ Kullberg, HD Vrijmoeth, F van de Schoor… - Bmj, 2020 - bmj.com
Lyme borreliosis is the most common vectorborne disease in the northern hemisphere. It
usually begins with erythema migrans; early disseminated infection particularly causes …

[HTML][HTML] Control of Lyme borreliosis and other Ixodes ricinus-borne diseases

H Sprong, T Azagi, D Hoornstra, AM Nijhof, S Knorr… - Parasites & vectors, 2018 - Springer
Lyme borreliosis (LB) and other Ixodes ricinus-borne diseases (TBDs) are diseases that
emerge from interactions of humans and domestic animals with infected ticks in nature …

Safety and immunogenicity of a novel multivalent OspA-based vaccine candidate against Lyme borreliosis: a randomised, phase 1 study in healthy adults

N Bézay, R Hochreiter, V Kadlecek… - The Lancet Infectious …, 2023 - thelancet.com
Background Lyme borreliosis, potentially associated with serious long-term complications, is
caused by the species complex Borrelia burgdorferi sensu lato. We investigated a novel …

[HTML][HTML] The novel Lyme borreliosis vaccine VLA15 shows broad protection against Borrelia species expressing six different OspA serotypes

P Comstedt, W Schüler, A Meinke, U Lundberg - PloS one, 2017 - journals.plos.org
We have previously shown that the Outer surface protein A (OspA) based Lyme borreliosis
vaccine VLA15 induces protective immunity in mice. Herein, we report the induction of …

[HTML][HTML] Recent advances in the molecular design of synthetic vaccines

LH Jones - Nature chemistry, 2015 - nature.com
Vaccines have typically been prepared using whole organisms. These are normally either
attenuated bacteria or viruses that are live but have been altered to reduce their virulence, or …

[HTML][HTML] The year that shaped the outcome of the OspA vaccine for human Lyme disease

RJ Dattwyler, M Gomes-Solecki - Npj Vaccines, 2022 - nature.com
The expansion of Lyme borreliosis endemic areas and the corresponding increase of
disease incidence have opened the possibility for greater acceptance of a vaccine. In this …

Safety, immunogenicity and dose response of VLA84, a new vaccine candidate against Clostridium difficile, in healthy volunteers

N Bézay, A Ayad, K Dubischar, C Firbas, R Hochreiter… - Vaccine, 2016 - Elsevier
Background Clostridium difficile infection (CDI) is the leading cause of antibiotic-associated
diarrhoea and colitis and the most common pathogen of health care-associated infections. In …