Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

Gut microbiota includes a vast collection of microorganisms residing within the
gastrointestinal tract. It is broadly recognized that the gut and brain are in constant …

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public …

The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …

The human body harbors a diverse ecosystem of microorganisms, including bacteria,
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …

Background Adolescent depression is becoming one of the major public health concerns,
because of its increased prevalence and risk of significant functional impairment and …

The spleen, an important tissue for the immune system, acts as a filter for blood within the
immune system. Accumulating evidence suggests that the spleen affects a number of brain …

Depression is a worldwide disease causing severe disability, morbidity, and mortality.
Despite abundant studies, the precise mechanisms underlying the pathophysiology of …

Chronic ethanol exposure (CEE), which can lead to neuroinflammation, is an increasing risk
factor for depression disorder, but the underlying mechanism is not clear. Recent …