Breast cancer remains a major global health challenge. Its rising incidence is attributed to
factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug …

Cancer cells undergo phenotypic switching (cancer cell plasticity) in response to
microenvironmental cues, including exposure to therapy/treatment. Phenotypic plasticity …

Here we present the generation and characterization of patient-derived organoids (PDOs)
from colorectal cancer patients. PDOs derived from two patients with TP53 mutations were …

Background SMYD3 has been found implicated in cancer progression. Its overexpression
correlates with cancer growth and invasion, especially in gastrointestinal tumors. SMYD3 …

Breast cancer is a life-threatening disease known for its extensive molecular heterogeneity.
The study of the breast cancer epigenome has revealed potential avenues for improving …

Melanoma, a highly aggressive skin cancer, is often driven by BRAF mutations, such as the
V600E mutation, which promotes cancer growth through the MAPK pathway and contributes …

Histone deacetylase inhibitors (HDACi) show high antineoplastic potential in preclinical
studies in various solid tumors, including gastric carcinoma; however, their use in clinical …

PRMT6 is a member of the protein arginine methyltransferase family, which participates in a
variety of physical processes and plays an important role in the occurrence and …

Cellular and molecular aspects of drug resistance in cancers | DARU Journal of
Pharmaceutical Sciences Skip to main content Springer Nature Link Account Menu Find a …

The intricate interaction between genetic instructions and environmental signals
orchestrates the destiny of cells. Regarding carcinogenesis, genetic abnormalities are not …