Genotoxicity is commonly evaluated during the chemical safety assessment together with
other toxicological endpoints. The micronucleus test is always included in many genotoxic …

The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics
on the market in Europe after 2013. In that context, the European Commission invited …

Abstract The Scientific Committee reviewed the current state‐of‐the‐science on genotoxicity
testing and provided a commentary and recommendations on genotoxicity testing strategies …

Misled by animal studies and basic research? Whenever we take a closer look at the
outcome of clinical trials in a field such as, most recently, stroke or septic shock, we see how …

The assessment of genotoxicity represents an essential component of the safety assessment
of all types of substances. Several in vitro tests are available at different stages of …

Systemic toxicity testing forms the cornerstone for the safety evaluation of substances.
Pressures to move from traditional animal models to novel technologies arise from various …

The major weakness of the current in vitro genotoxicity test systems is the inability of the
indicator cells to express metabolic enzymes needed for the activation and detoxification of …

Objectives According to the 2007 National Research Council report Toxicology for the
Twenty-First Century, modern methods (eg,“omics,” in vitro assays, high-throughput testing …

The comet assay has become one of the methods of choice for the evaluation and
measurement of DNA damage. It is sensitive, quick to perform and relatively affordable for …

Carbon nanotubes (CNTs) were the first nanomaterials to be evaluated by the International
Agency for Research on Cancer (IARC). The categorization as possibly carcinogenic agent …