Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms

A Anjum, MD Yazid, M Fauzi Daud, J Idris… - International journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes
major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and …

Modern trends for peripheral nerve repair and regeneration: beyond the hollow nerve guidance conduit

CR Carvalho, JM Oliveira, RL Reis - Frontiers in bioengineering and …, 2019 - frontiersin.org
Peripheral nerve repair and regeneration remains among the greatest challenges in tissue
engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are …

Regenerative rehabilitation with conductive biomaterials for spinal cord injury

EA Kiyotake, MD Martin, MS Detamore - Acta biomaterialia, 2022 - Elsevier
The individual approaches of regenerative medicine efforts alone and rehabilitation efforts
alone have not yet fully restored function after severe spinal cord injury (SCI). Regenerative …

Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential

BF Ribeiro, BC da Cruz, BM de Sousa, PD Correia… - Brain, 2023 - academic.oup.com
Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …

Spinal cord repair: from cells and tissue engineering to extracellular vesicles

S Guo, I Redenski, S Levenberg - Cells, 2021 - mdpi.com
Spinal cord injury (SCI) is a debilitating condition, often leading to severe motor, sensory, or
autonomic nervous dysfunction. As the holy grail of regenerative medicine, promoting spinal …

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury

B Yang, F Zhang, F Cheng, L Ying, C Wang, K Shi… - Cell Death & …, 2020 - nature.com
Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such
patients had to suffer irreversible loss of motor or sensory function, and thereafter enormous …

[HTML][HTML] Advanced approaches to regenerate spinal cord injury: the development of cell and tissue engineering therapy and combinational treatments

J Saremi, N Mahmoodi, M Rasouli, FE Ranjbar… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a central nervous system (CNS) devastate event that is commonly
caused by traumatic or non-traumatic events. The reinnervation of spinal cord axons is …

Multi-target approaches to CNS repair: olfactory mucosa-derived cells and heparan sulfates

SL Lindsay, GA McCanney, AG Willison… - Nature Reviews …, 2020 - nature.com
Spinal cord injury (SCI) remains one of the biggest challenges in the development of
neuroregenerative therapeutics. Cell transplantation is one of numerous experimental …

[Retracted] Recent Advances in Cell and Functional Biomaterial Treatment for Spinal Cord Injury

T Liu, W Zhu, X Zhang, C He, X Liu… - BioMed Research …, 2022 - Wiley Online Library
Spinal cord injury (SCI) is a devastating central nervous system disease caused by
accidental events, resulting in loss of sensory and motor function. Considering the multiple …

Schwann cell-derived exosomal vesicles: a promising therapy for the injured spinal cord

M Ghosh, DD Pearse - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular
milieu. Within these nanovesicles reside a multitude of bioactive molecules, which …