Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …

It has now become accepted that the immune system and neuroendocrine system form an
integrated part of our physiology. Immunological defense mechanisms act in concert with …

The glucocorticoid and mineralocorticoid receptors (GR and MR, respectively) have distinct,
yet overlapping physiological and pathophysiological functions. There are indications that …

1. Introduction 2. Molecular Regulation of the Hypothalamic–Pituitary–Interrenal (HPI) Axis
2.1. Hypothalamus 2.2. Pituitary 2.3. Head Kidney (Interrenal Tissue) 3. Genomic Cortisol …

Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young,
appearing in the fossil record during the Cambrian explosion about 542 to 515 million years …

Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind
DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to …

The mineralocorticoid receptor (MR) is descended from a corticoid receptor (CR), which has
descendants in lamprey and hagfish, cyclostomes (jawless fish), a taxon that evolved at the …

In aquaculture facilities fish welfare could be compromised due to stressors. Fish deal with
stress, inter alia, through the activation of the hypothalamic-pituitary-interrenal endocrine …

Mineralocorticoid and glucocorticoid receptors (MRs and GRs) constitute a functionally
important dual receptor system detecting and transmitting circulating corticosteroid signals …

The membrane efflux transporter P-glycoprotein (P-gp,[ABCB1, MDR1]) exports a wide
range of xenobiotic compounds, resulting in a continuous first line of defense against …