Vitamin requirements and biosynthesis in Saccharomyces cerevisiae
Chemically defined media for yeast cultivation (CDMY) were developed to support fast
growth, experimental reproducibility, and quantitative analysis of growth rates and biomass …
growth, experimental reproducibility, and quantitative analysis of growth rates and biomass …
On the evolution of coenzyme biosynthesis
A Kirschning - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 The report provides a broad approach to deciphering the evolution of
coenzyme biosynthetic pathways. Here, these various pathways are analyzed with respect …
coenzyme biosynthetic pathways. Here, these various pathways are analyzed with respect …
Biomimetic chirality sensing with pyridoxal-5′-phosphate
SL Pilicer, PR Bakhshi, KW Bentley… - Journal of the American …, 2017 - ACS Publications
Pyridoxal-5′-phosphate (PLP) is introduced to a biomimetic indicator displacement assay
for simultaneous determination of the absolute configuration, enantiomeric composition and …
for simultaneous determination of the absolute configuration, enantiomeric composition and …
Structural dynamics in the evolution of a bilobed protein scaffold
G Gouridis, YA Muthahari, M de Boer… - Proceedings of the …, 2021 - National Acad Sciences
Novel biophysical tools allow the structural dynamics of proteins and the regulation of such
dynamics by binding partners to be explored in unprecedented detail. Although this has …
dynamics by binding partners to be explored in unprecedented detail. Although this has …
Thiamine metabolism genes in diatoms are not regulated by thiamine despite the presence of predicted riboswitches
M Llavero‐Pasquina, K Geisler, A Holzer… - New …, 2022 - Wiley Online Library
Thiamine pyrophosphate (TPP), an essential co‐factor for all species, is biosynthesised
through a metabolically expensive pathway regulated by TPP riboswitches in bacteria, fungi …
through a metabolically expensive pathway regulated by TPP riboswitches in bacteria, fungi …
Rediscovering a forgotten system of symbiosis: historical perspective and future potential
VG Martinson - Genes, 2020 - mdpi.com
While the majority of symbiosis research is focused on bacteria, microbial eukaryotes play
important roles in the microbiota and as pathogens, especially the incredibly diverse Fungi …
important roles in the microbiota and as pathogens, especially the incredibly diverse Fungi …
A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria
K Sakaki, K Ohishi, T Shimizu, I Kobayashi… - Nature Chemical …, 2020 - nature.com
In biotin biosynthesis, the conversion of pimeloyl intermediates to biotin is catalyzed by a
universal set of four enzymes: BioF, BioA, BioD and BioB. We found that the gene …
universal set of four enzymes: BioF, BioA, BioD and BioB. We found that the gene …
Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity
Thiamin (vitamin B1) is an essential micronutrient needed as a cofactor for many central
metabolic enzymes. Animals must have thiamin in their diet, whereas bacteria, fungi, and …
metabolic enzymes. Animals must have thiamin in their diet, whereas bacteria, fungi, and …
Redesigning thiamin synthesis: Prospects and potential payoffs
Thiamin is essential for plant growth but is short-lived in vivo and energetically very costly to
produce–a combination that makes thiamin biosynthesis a prime target for improvement by …
produce–a combination that makes thiamin biosynthesis a prime target for improvement by …
Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis in Candida albicans
The yeast thiamin pyrimidine synthase THI5p catalyzes one of the most complex organic
rearrangements found in primary metabolism. In this reaction, the active site His66 and PLP …
rearrangements found in primary metabolism. In this reaction, the active site His66 and PLP …