Pathogen infection routes and host innate immunity: Lessons from insects
I Eleftherianos, G Tafesh-Edwards, A Mohamed - Immunology Letters, 2022 - Elsevier
Recent advances in insect-pathogen interactions have started to reveal the role of insect
tissues and organs as natural infection routes for parasites and microbial pathogens. Here …
tissues and organs as natural infection routes for parasites and microbial pathogens. Here …
Drosophila melanogaster as a High-Throughput Model for Host–Microbiota Interactions
Microbiota research often assumes that differences in abundance and identity of
microorganisms have unique influences on host physiology. To test this concept …
microorganisms have unique influences on host physiology. To test this concept …
Host-pathogen coevolution increases genetic variation in susceptibility to infection
It is common to find considerable genetic variation in susceptibility to infection in natural
populations. We have investigated whether natural selection increases this variation by …
populations. We have investigated whether natural selection increases this variation by …
Addicted? Reduced host resistance in populations with defensive symbionts
Heritable symbionts that protect their hosts from pathogens have been described in a wide
range of insect species. By reducing the incidence or severity of infection, these symbionts …
range of insect species. By reducing the incidence or severity of infection, these symbionts …
Historical contingency drives compensatory evolution and rare reversal of phage resistance
R Debray, N De Luna, B Koskella - Molecular Biology and …, 2022 - academic.oup.com
Bacteria and lytic viruses (phages) engage in highly dynamic coevolutionary interactions
over time, yet we have little idea of how transient selection by phages might shape the future …
over time, yet we have little idea of how transient selection by phages might shape the future …
Experimental evolution for improved postinfection survival selects for increased disease resistance in Drosophila melanogaster
Disease resistance (defined as the host capacity to limit systemic infection intensity) and
disease tolerance (defined as the host capacity to limit infection-induced damage) are 2 …
disease tolerance (defined as the host capacity to limit infection-induced damage) are 2 …
No apparent cost of evolved immune response in Drosophila melanogaster
Maintenance and deployment of the immune system are costly and are hence predicted to
trade-off with other resource-demanding traits, such as reproduction. We subjected this …
trade-off with other resource-demanding traits, such as reproduction. We subjected this …
Complex Coding and Regulatory Polymorphisms in a Restriction Factor Determine the Susceptibility of Drosophila to Viral Infection
It is common to find that major-effect genes are an important cause of variation in
susceptibility to infection. Here we have characterized natural variation in a gene called …
susceptibility to infection. Here we have characterized natural variation in a gene called …
Fly immunity comes of age: The utility of Drosophila as a model for studying variation in immunosenescence
MK Corbally, JC Regan - Frontiers in aging, 2022 - frontiersin.org
The global demographic is shifting towards an aged population (United Nations, 2019). Yet,
it is our oldest members of society that are the most vulnerable to infectious disease …
it is our oldest members of society that are the most vulnerable to infectious disease …
Experimental evolution of insect immune memory versus pathogen resistance
Under strong pathogen pressure, insects often evolve resistance to infection. Many insects
are also protected via immune memory (immune priming), whereby sublethal exposure to a …
are also protected via immune memory (immune priming), whereby sublethal exposure to a …