Epigenetic modifications in stress response genes associated with childhood trauma

S Jiang, L Postovit, A Cattaneo, EB Binder… - Frontiers in …, 2019 - frontiersin.org
Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …

The role of regulatory variation in complex traits and disease

FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

GraphR: Accelerating graph processing using ReRAM

L Song, Y Zhuo, X Qian, H Li… - 2018 IEEE International …, 2018 - ieeexplore.ieee.org
Graph processing recently received intensive interests in light of a wide range of needs to
understand relationships. It is well-known for the poor locality and high memory bandwidth …

Defining the consequences of genetic variation on a proteome-wide scale

JM Chick, SC Munger, P Simecek, EL Huttlin, K Choi… - Nature, 2016 - nature.com
Genetic variation modulates protein expression through both transcriptional and post-
transcriptional mechanisms. To characterize the consequences of natural genetic diversity …

[图书][B] Behavioral genetics

R Plomin - 2008 - books.google.com
Behavioral Genetics, Fifth Edition provides an engaging and clear overview of human and
animal behavioral genetics that is designed to introduce students in the behavioral …

Multiple-trait genomic selection methods increase genetic value prediction accuracy

Y Jia, JL Jannink - Genetics, 2012 - academic.oup.com
Genetic correlations between quantitative traits measured in many breeding programs are
pervasive. These correlations indicate that measurements of one trait carry information on …

Relative impact of nucleotide and copy number variation on gene expression phenotypes

BE Stranger, MS Forrest, M Dunning, CE Ingle… - Science, 2007 - science.org
Extensive studies are currently being performed to associate disease susceptibility with one
form of genetic variation, namely, single-nucleotide polymorphisms (SNPs). In recent years …

Genetics of gene expression and its effect on disease

V Emilsson, G Thorleifsson, B Zhang, AS Leonardson… - Nature, 2008 - nature.com
Common human diseases result from the interplay of many genes and environmental
factors. Therefore, a more integrative biology approach is needed to unravel the complexity …

Autism‐like behavioral phenotypes in BTBR T+ tf/J mice

HG McFarlane, GK Kusek, M Yang… - Genes, Brain and …, 2008 - Wiley Online Library
Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology. Mouse
models with face validity to the core symptoms offer an experimental approach to test …

An integrative genomics approach to infer causal associations between gene expression and disease

EE Schadt, J Lamb, X Yang, J Zhu, S Edwards… - Nature …, 2005 - nature.com
A key goal of biomedical research is to elucidate the complex network of gene interactions
underlying complex traits such as common human diseases. Here we detail a multistep …