Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

Over the last seven decades, a significant scientific contribution took place in the delineation
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …

Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …

Cytotoxic chemotherapy or radiotherapy of cancer is limited by serious, sometimes life-
threatening, side effects that arise from toxicities to sensitive normal cells because the …

Transplantation of donor-derived islets into the liver is a successful cellular replacement
therapy for individuals with diabetes. However, the hepatic vasculature is not an optimal …

Vascular endothelial growth factor A (VEGF-A), the founding member of the vascular
permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with …

Development of hypoxic regions is an indicator of poor prognosis in many tumors. Here, we
demonstrate that HIF1α, the direct effector of hypoxia, partly through increases in SDF1α …

The process by which normal cells become progressively transformed to malignancy is now
known to require the sequential acquisition of mutations which arise as a consequence of …

We demonstrate a novel tumor-promoting role of myeloid immune suppressor Gr+ CD11b+
cells, which are evident in cancer patients and tumor-bearing animals. These cells constitute …

Vascular endothelial growth factor-A (VEGF), a potent angiogenic factor, is also implicated in
self-renewal in several normal tissue types. VEGF has been shown to drive malignant stem …