Iron is an essential component in many biological processes in the human body. It is critical
for the visual phototransduction cascade in the retina. However, excess iron can be toxic …

In a search of new bone proteins, the glycoprotein YKL-40 was identified in 1989 to be
secreted in vitro in large amount by the human osteosarcoma cell line MG63. The protein …

Rod and cone photoreceptors are light-sensing cells in the human retina. Rods are
dominant in the peripheral retina, whereas cones are enriched in the macula, which is …

Recent developments in imaging technologies now allow the documentation, qualitative and
quantitative evaluation of peripheral retinal lesions. As wide field retinal imaging, capturing …

The human retina is a complex tissue responsible for detecting photons of light and
converting information from these photons into the neurochemical signals interpreted as …

Single-cell RNA-seq is a powerful tool in decoding the heterogeneity in complex tissues by
generating transcriptomic profiles of the individual cell. Here, we report a single-nuclei RNA …

A wide range of ocular diseases can present with serous subretinal fluid in the macula and
therefore clinically mimic central serous chorioretinopathy (CSC). In this manuscript, we …

Single-cell RNA sequencing has revolutionized ocular gene expression studies. This
technology has enabled researchers to identify expression signatures for rare cell types and …

The cone and cone–rod dystrophies form part of a heterogeneous group of retinal disorders
that are an important cause of visual impairment in children and adults. There have been …

An understanding of the diabetes-induced alterations in vitreous protein composition in the
absence and in the presence of proliferative diabetic retinopathy (PDR) may provide insights …