Macrophages play a key role in the pathophysiology of rheumatoid arthritis (RA). Notably,
positive correlations have been reported between synovial macrophage infiltration and …

Antivitamins represent a broad class of compounds that counteract the essential effects of
vitamins. The symptoms triggered by such antinutritional factors resemble those of vitamin …

The dihydrofolate reductase (DHFR) is a significant target in cancer, microbial infection,
fungal infection, malaria, leishmaniasis, and tuberculosis, among other diseases. The DHFR …

2-Amino-4-oxo-6-substituted-pyrrolo [2, 3-d] pyrimidine antifolate thiophene regioisomers of
AGF94 (4) with a thienoyl side chain and three-carbon bridge lengths [AGF150 (5) and …

This review considers the “promise” of exploiting the proton-coupled folate transporter
(PCFT) for selective therapeutic targeting of cancer. PCFT was discovered in 2006 and was …

Targeted antifolates with heteroatom replacements of the carbon vicinal to the phenyl ring in
1 by N (4), O (8), or S (9), or with N-substituted formyl (5), acetyl (6), or trifluoroacetyl (7) …

Novel fluorinated 2-amino-4-oxo-6-substituted pyrrolo [2, 3-d] pyrimidine analogues 7–12
were synthesized and tested for selective cellular uptake by folate receptors (FRs) α and β or …

Peptides can operate as therapeutic agents that sit within a privileged space between small
molecules and larger biologics. Despite examples of their potential to regulate receptors and …

Introduction The proton-coupled folate transporter (PCFT; SLC46A1) was discovered in
2006 as the principal mechanism by which folates are absorbed in the intestine and the …

Sulfur–lone pair interactions are important conformational control elements in sulfur-
containing heterocycles that abound in pharmaceuticals, natural products, agrochemicals …